Last update Dec. 10, 2022

Pinaverium Bromide

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

A Calcium channel blocker with spasmolytic activity on the intestine and antimuscarinic effects. It is used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract. Oral administration.

At latest update no published data were found on excretion into breast milk.

Its pharmacokinetic data (moderately high molecular weight and high protein binding) make unlikely the passage into milk in significant amounts.

Its very low oral bioavailability hinders its passage into infant's plasma from ingested milk, except in preterm infants and immediate neonatal period, since they may exhibit an increased intestinal permeability.

Although antimuscarinics can decrease prolactin production (Müller 1983, Masala 1982), once lactation is established, milk production depends more on the repeated stimulation of suckling than on prolactin levels

Alternatives

  • Linaclotide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Otilonium Bromide (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Rifaximin ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Pinaverium Bromide in other languages or writings:

Group

Pinaverium Bromide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Pinaverium Bromide in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. < 1 %
Molecular weight 591 daltons
Protein Binding 97 %
Tmax 1 hours
1.5 hours

References

  1. BGP. Pinaverium. Product Monograph. 2015 Full text (in our servers)
  2. Annaházi A, Róka R, Rosztóczy A, Wittmann T. Role of antispasmodics in the treatment of irritable bowel syndrome. World J Gastroenterol. 2014 Abstract
  3. AEMPS. Pinaverio. Ficha técnica. 2014 Full text (in our servers)
  4. Müller EE, Locatelli V, Cella S, Peñalva A, Novelli A, Cocchi D. Prolactin-lowering and -releasing drugs. Mechanisms of action and therapeutic applications. Drugs. 1983 Apr;25(4):399-432. Review. Abstract
  5. Masala A, Alagna S, Devilla L, Rovasio PP, Rassa S, Faedda R, Satta A. Muscarinic receptor blockade by pirenzepine: effect on prolactin secretion in man. J Endocrinol Invest. 1982 Jan-Feb;5(1):53-5. Abstract

Total visits

143,372

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM