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Pholcodine is a centrally acting opioid antitussive that has actions and uses similar to those of dextromethorphan. It has a mild sedative effect and no analgesic effect. May cause respiratory depression and hypotension like codeine. Does not cause addiction (Blanchard 2013). It is administered orally three or four times a day.
Since the last update we have not found published data on its excretion in breastmilk.
Its pharmacokinetic data do not allow a good prediction of the possible excretion in breast milk, because while its low binding to plasma proteins and long half-life would facilitate it, its very large volume of distribution would make it difficult.
The administration of pholcodine causes the production of anti-curare antibodies that persist for several years, with the risk of severe anaphylaxis during anesthesia. (Florvaag 2012, Guttormsen 2010, Harboe 2007)
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.