Last update May 1, 2022

Perprazole

Compatible

Safe substance and/or breastfeeding is the best option.

Esomeprazole is a proton pump inhibitor (PPI), S enantiomer of Omeprazole, with the same actions and uses. Indicated in the treatment of peptic ulcer and gastroesophageal reflux. Oral administration once daily.

Like omeprazole (Nava 2006), it is excreted in breast milk in clinically insignificant amounts (Saito 2020) and no problems have been observed in an infant whose mother have taken it. (Saito 2020)

Since it's neutralized by the acid pH of stomach, capsules with enteric coated granules are used. Because of this, it is thought that the small quantity of Esomeprazole that may reach the breast milk would be neutralized by infant's stomach. In addition, absorption is greatly decreased by the presence of food.

Esomeprazole has been used for treatment of newborn and premature infants. (Omari 2009)

Hyperprolactinemia and galactorrhea have been reported by the use of Esomeprazole. (Pipaliya 2016)


See below the information of this related product:

  • Omeprazole (Safe substance and/or breastfeeding is the best option.)

Alternatives

  • Famotidine (Safe substance and/or breastfeeding is the best option.)
  • Nizatidine (Safe substance and/or breastfeeding is the best option.)
  • Omeprazole (Safe substance and/or breastfeeding is the best option.)
  • Pantoprazole (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Perprazole is also known as Esomeprazole. Here it is a list of alternative known names::


Perprazole in other languages or writings:

Group

Perprazole belongs to this group or family:

Tradenames

Main tradenames from several countries containing Perprazole in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 64 - 89 %
Molecular weight 767 daltons
Protein Binding 97 %
VD 0.23 l/Kg
Tmax 1.5 hours
T½ 1 - 1.4 hours
M/P ratio 0.07 -
Theoretical Dose 0.003 mg/Kg/d
Relative Dose 1.8 %
Ped.Relat.Dose 0.3 - 1.2 %

References

  1. Ashfaq M, Haroon MZ, Alkahraman YM. Proton pump inhibitors therapy and risk of hyperprolactinemia with associated sexual disorders. Endocr Regul. 2022 Apr 30;56(2):134-147. Abstract Full text (link to original source)
  2. Saito J, Yakuwa N, Sandaiji N, Kawasaki H, Kaneko K, Suzuki T, Yamatani A, Sago H, Murashima A. Esomeprazole During Pregnancy and Lactation: Esomeprazole Levels in Maternal Serum, Cord Blood, Breast Milk, and the Infant's Serum. Breastfeed Med. 2020 Jul 7. Abstract
  3. Pipaliya N, Solanke D, Rathi C, Patel R, Ingle M, Sawant P. Esomeprazole induced galactorrhea: a novel side effect. Clin J Gastroenterol. 2016 Abstract
  4. Esomeprazol Ficha técnica 2012 Full text (in our servers)
  5. Omari T, Lundborg P, Sandström M, Bondarov P, Fjellman M, Haslam R, Davidson G. Pharmacodynamics and systemic exposure of esomeprazole in preterm infants and term neonates with gastroesophageal reflux disease. J Pediatr. 2009 Abstract
  6. Nava-Ocampo AA, Velázquez-Armenta EY, Han JY, Koren G. Use of proton pump inhibitors during pregnancy and breastfeeding. Can Fam Physician. 2006 Abstract Full text (link to original source) Full text (in our servers)
  7. Andersson T, Hassan-Alin M, Hasselgren G, Röhss K, Weidolf L. Pharmacokinetic studies with esomeprazole, the (S)-isomer of omeprazole. Clin Pharmacokinet. 2001 Abstract

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