Last update Dec. 12, 2022

Pargeverine Hydrochloride

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

A product which has antimuscarinic/anticholinergic effects, similar in action to atropine. It has antispasmodic properties on smooth muscle. Indicated in functional conditions of the intestine, gall bladder, uterus and bladder.

Since the last update, we have not found published data on its excretion in breastmilk.

Its high binding to plasma proteins makes its excretion in milk unlikely, as indicated by the manufacturer (Unipharm 2018).

There is hardly any published scientific data on this product: fewer than 10 articles (only 4 on humans) collected in PubMed and the last one dates from 2001.

Until there is more published information about this drug in relation to breastfeeding, better known alternatives may be preferable, especially during the neonatal period and in case of prematurity.

Although antimuscarinics can decrease prolactin production (Müller 1983, Masala 1982, De Martino 1980, Bizarro 1980), once lactation is established, milk production depends more on the repeated stimulation of suckling than on prolactin levels.

The literature on this drug is scarce and it is sold in few countries.

During breastfeeding it may be prudent to avoid it or take a minimum dose over short periods of time, monitoring the production of milk, especially in the first weeks postpartum. It is also advisable to monitor anticholinergic symptoms in the infant: dry mouth, constipation...


  • Atropine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Linaclotide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Otilonium Bromide (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Rifaximin ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Pargeverine Hydrochloride is also known as

Pargeverine Hydrochloride in other languages or writings:


Pargeverine Hydrochloride belongs to this group or family:


Main tradenames from several countries containing Pargeverine Hydrochloride in its composition:


Variable Value Unit
Oral Bioavail. 75 ± 13 %
Molecular weight 374 daltons
Protein Binding 91 - 97 %
VD 0.12 - 2 l/Kg
Tmax 0.9 - 1 hours
4 hours
M/P ratio 0.1 -


  1. Unipharm. Propinox (espasmo dolofor). Ficha técnica. 2018 Full text (link to original source) Full text (in our servers)
  2. Roemmers. Propinox (Sertal). Prospecto. 2017 Full text (in our servers)
  3. de los Santos AR, Zmijanovich R, Pérez Macri S, Martí ML, Di Girolamo G. Antispasmodic/analgesic associations in primary dysmenorrhea double-blind crossover placebo-controlled clinical trial. Int J Clin Pharmacol Res. 2001 Abstract
  4. Müller EE, Locatelli V, Cella S, Peñalva A, Novelli A, Cocchi D. Prolactin-lowering and -releasing drugs. Mechanisms of action and therapeutic applications. Drugs. 1983 Apr;25(4):399-432. Review. Abstract
  5. Masala A, Alagna S, Devilla L, Rovasio PP, Rassa S, Faedda R, Satta A. Muscarinic receptor blockade by pirenzepine: effect on prolactin secretion in man. J Endocrinol Invest. 1982 Jan-Feb;5(1):53-5. Abstract
  6. Bizzarro A, Iannucci F, Tolino A, Soricelli A, Guarino G, Verdoliva A. Inhibiting effect of atropine on prolactin blood levels after stimulation with TRH. Clin Exp Obstet Gynecol. 1980 Abstract
  7. De Martino F, De Matteo A, L'Abbate V, Soricelli A, Fontana A, Petrenga E, Cesarone M. [Inhibitory effects of atropine on serum prolactin levels after TRH stimulation]. Boll Soc Ital Biol Sper. 1980 Abstract

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