Last update July 31, 2018
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Papaverine is also known as
Papaverine in other languages or writings:
Papaverine belongs to these groups or families:
Main tradenames from several countries containing Papaverine in its composition:
|Oral Bioavail.||28 (5 - 99)||%|
|Protein Binding||90 - 95||%|
|T½||0.5 - 2. 2||hours|
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e-lactancia is a resource recommended by Asociación Pro Lactancia Materna (APROLAM) of Mexico
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An alkaloid derived from the opium of the Papaver somniferum plant or prepared synthetically. Not structurally related to the rest of opium alkaloids such as morphine or codeine.
It has a relaxant effect on the vascular system, bronchial musculature and the gastrointestinal, biliary and urinary tracts (American Regent 2017).
Indicated in coronary, pulmonary, peripheral or cerebral vascular spasms and gastrointestinal, ureteral or biliary colic. Oral, intramuscular or intravenous administration every 3 to 12 hours.
Since the last update we have not found published data on its excretion in breastmilk.
Its pharmacokinetic data (large volume of distribution, high percentage of protein binding, short half-life, pKa acid) make transfer to milk in significant quantities unlikely.
Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity.