Last update Sept. 4, 2022
It is a serotonin (5-HT3) antagonist used for the prevention and treatment of nausea and vomiting caused by chemotherapy and surgery. Oral (alone or associated with netupitant) or intravenous administration.
Since the last update we have not found published data on its excretion in breastmilk.
Its pharmacokinetic data do not allow a good prediction of its possible excretion in breast milk, since while its low protein binding and low molecular weight, its very large volume of distribution would make it difficult.
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2006 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM