Last update Oct. 15, 2024

Oxacillin. Oxacillin Sodium

Compatible

Safe product and/or breastfeeding is the best option.

It is an isoxazolylpenicillin used similarly to flucloxacillin for the treatment of staphylococcal infections resistant to benzylpenicillin. Oral, intramuscular or intravenous administration every 4 to 6 hours.

Like most penicillins, it is excreted in breast milk in clinically insignificant amounts. (Zhang 1997, Peiker 1986, Matsuda 1984, Kulakov 1981)

Small concentrations of oxacillin have been detected in urine of newborns breastfed by mothers treated with this antibiotic. (Peiker 1986)

Medication for pediatric use, even in newborns.

Although rare, it is necessary to take into account the possibility of transient gastroenteritis due to alteration of the intestinal flora in infants whose mothers take antibiotics.

Alternatives

We do not have alternatives for Oxacillin. Oxacillin Sodium since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Oxacillin. Oxacillin Sodium in other languages or writings:

Group

Oxacillin. Oxacillin Sodium belongs to this group or family:

Tradenames

Main tradenames from several countries containing Oxacillin. Oxacillin Sodium in its composition:

List of 11 tradenames

Pharmacokinetics

Variable Value Unit
Molecular weight 441 daltons
Protein Binding 94 %
VD 0.11 l/Kg
pKa 3.75 -
T½ 0.3 - 0.5 hours
Theoretical Dose 0.006 - 0.1 mg/Kg/d
Relative Dose 0. 3 - 1.2 %

References

  1. Zhang Y, Zhang Q, Xu Z. [Tissue and body fluid distribution of antibacterial agents in pregnant and lactating women]. Zhonghua Fu Chan Ke Za Zhi. 1997 Abstract
  2. Peiker G, Schröder S. [The concentration of oxacillin and ampicillin (Penstabil) in serum and mother's milk in puerperal mastitis]. Pharmazie. 1986 Nov;41(11):793-5. German. Abstract
  3. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. Abstract
  4. Kulakov VI, Zak IR, Kulikova NN, Smekuna FA. [Body pharmacokinetics of methicillin, oxacillin and cephaloridine in puerperal mastitis]. Antibiotiki. 1981 Feb;26(2):110-3. Russian. Abstract

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