Last update July 1, 2015

Orphenadrine

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Anti-muscarinic analogue agent similar to Diphenhydramine with no sedative effect. Used for the treatment of muscle spasms and Parkinson Disease.

At latest update, relevant published data on excretion into breast milk were not found.

Its pharmacokinetics (moderately high molecular weight and high protein-binding capacity) makes excretion into breast milk in significant amount be unlikely.

Until more data on this medication is available, safer alternative drugs are preferred especially in premature babies or during the neonatal period.

Whenever used while breastfeeding take the lowest dose as possible along with a follow-up for somnolence and troubles of the infant with feeding.

It is not commercially available in Spain.

Alternatives

  • Baclofen (Safe substance and/or breastfeeding is the best option.)
  • Methocarbamol (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Orphenadrine is also known as


Orphenadrine in other languages or writings:

Groups

Orphenadrine belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Orphenadrine in its composition:

List of 11 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 90 %
Molecular weight 462 daltons
Protein Binding 95 %
Tmax 2 - 4 hours
T½ 16 - 31 hours

References

  1. eMC. Orphenadrine. Drug Summary. 2013 Full text (in our servers)
  2. Rosemont Pharmaceuticals Ltd. Orphenadrine. Drug Summary. 2013 Full text (in our servers)
  3. Farmical. Orfenadrina. Ficha técnica. 2010 Full text (in our servers)
  4. Lee SY, Oh HJ, Kim JW, Kim YG, Moon CJ, Lee EH. Pharmacokinetic study of orphenadrine using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Abstract
  5. Labout JJ, Thijssen Ct, Keijser GG, Hespe W. Difference between single and multiple dose pharmacokinetics of orphenadrine hydrochloride in man. Eur J Clin Pharmacol. 1982 Abstract

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