Last update May 29, 2025

Non-Hormonal Vaginal Lubricant

Compatible

Safe product and/or breastfeeding is the best option.

Non-hormonal vaginal lubricants are basically compounded by water or oil, either natural or mineral, or silicone. They may contain water, vegetable oils, glycerin, silicone, citric acid, polyethylene glycol (PEG), polypropylene glycol (PPG), hyaluronic acid and other products.

It must be ensured that the products are authorised and non-toxic, as they can alter the vaginal microbiome and vaginal absorption can be significant and the products can pass into the bloodstream without any prior metabolisation. (Nicole W 2014, Fashemi 2013, Brown 2013, Gupta 2011, Hussain 2005)

Non-hormonal lubricants (creams, gels or eggs) intended to treat a possible dryness of vagina due to hypoestrogenism during lactation, diabetes, after treatment for breast or gynecologic cancer are preferable to topical oestrogens, which are well absorbed vaginally. (Tourgeman 2001 & 1999)

Lubricants, in order to avoid any harm to the vaginal mucosa and the health of women, must meet some requirements, among which are included: ideal osmolarity should be less of 380 mOsm / Kg (by no means over 1,200 mOsm / Kg: less than 9% of glycols), pH 4.5, should neither contain spermicides (nonoxynol-9) ,nor drugs (eg anesthetics), nor herbal products, nor polyquaternary compounds, nor products that may alter the wholeness of condoms. (Cunha 2014m, WHO/UNFPA/FHI 2012, Wolf 2012)


See below the information of these related products:

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

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Tradenames

Main tradenames from several countries containing Non-Hormonal Vaginal Lubricant in its composition:

References

  1. Hickey M, Marino JL, Braat S, Wong S. A randomized, double-blind, crossover trial comparing a silicone- versus water-based lubricant for sexual discomfort after breast cancer. Breast Cancer Res Treat. 2016 Abstract
  2. Huffman LB, Hartenbach EM, Carter J, Rash JK, Kushner DM. Maintaining sexual health throughout gynecologic cancer survivorship: A comprehensive review and clinical guide. Gynecol Oncol. 2016 Abstract
  3. Herbenick D, Reece M, Schick V, Sanders SA, Fortenberry JD. Women's use and perceptions of commercial lubricants: prevalence and characteristics in a nationally representative sample of American adults. J Sex Med. 2014 Abstract
  4. Nicole W. A question for women's health: chemicals in feminine hygiene products and personal lubricants. Environ Health Perspect. 2014 Abstract
  5. Cunha AR, Machado RM, Palmeira-de-Oliveira A, Martinez-de-Oliveira J, das Neves J, Palmeira-de-Oliveira R. Characterization of commercially available vaginal lubricants: a safety perspective. Pharmaceutics. 2014 Abstract
  6. Fashemi B, Delaney ML, Onderdonk AB, Fichorova RN. Effects of feminine hygiene products on the vaginal mucosal biome. Microb Ecol Health Dis. 2013 Abstract
  7. Brown JM, Hess KL, Brown S, Murphy C, Waldman AL, Hezareh M. Intravaginal practices and risk of bacterial vaginosis and candidiasis infection among a cohort of women in the United States. Obstet Gynecol. 2013 Abstract
  8. WHO/UNFPA/FHI360. Use and procurement of additional lubricants for male and female condoms. Advisory note. 2012 Full text (link to original source) Full text (in our servers)
  9. Wolf LK. Studies raise questions about safety of personal lubricants. Chem Eng News. 2012;90(50):46–47 2012 Full text (link to original source) Full text (in our servers)
  10. Gupta S, Gabrani R, Ali J, Dang S. Exploring novel approaches to vaginal drug delivery. Recent Pat Drug Deliv Formul. 2011 Abstract
  11. Hussain A, Ahsan F. The vagina as a route for systemic drug delivery. J Control Release. 2005 Abstract
  12. Tourgeman DE, Slater CC, Stanczyk FZ, Paulson RJ. Endocrine and clinical effects of micronized estradiol administered vaginally or orally. Fertil Steril. 2001 Abstract
  13. Tourgeman DE, Gentzchein E, Stanczyk FZ, Paulson RJ. Serum and tissue hormone levels of vaginally and orally administered estradiol. Am J Obstet Gynecol. 1999 Abstract

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