Last update June 5, 2021

Nitrofurantoin

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

It is an antibacterial used in the treatment and prophylaxis of uncomplicated lower urinary-tract infections.
Oral administration four times daily.

Excretion into breast milk is clinically non-significant or undetectable (Gerk 2001, Pons 1990, Varsano 1973, Hosbach 1967) with no side-effects observed among breastfed infants from treated mothers except rare cases of diarrhea (Ito 1993).

Do not use in premature infants, while the infant is younger of two weeks of age or suffers hyperbilirubinemia or G-6-P dehydrogenase (G6PD) deficiency to avoid likelihood of hemolysis (Zao 2014, WHO 2002, AAP 2001, Mactal 2001).

Be aware the possibility of developing diarrhea due to bacterial flora imbalance.

Expert authors consider the use of monoclonal antibodies to be safe during breastfeeding (Hale, LactMed, Briggs 2015, Schaefer2015, Zao 2014, Amir 2011, Mactal 2001).
American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001).
List of WHO essential medicines: compatible with breastfeeding (WHO / UNICEF 2002).

Alternatives

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Nitrofurantoin in other languages or writings:

Group

Nitrofurantoin belongs to this group or family:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 40 - 90 %
Molecular weight 238 daltons
Protein Binding 60 - 90 %
VD 0,8 l/Kg
pKa 8,2 -
Tmax 1,5 - 5 hours
T1/2 0,3 - 1 hours
M/P ratio 0,3 - 6 -
Theoretical Dose 0,075 - 0,41 mg/Kg/d
Relative Dose 1 - 6 %
Ped.Relat.Dose 1 - 6 %

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