Last update Sept. 4, 2022


Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Aprepitant is a neurokinin-1 receptor antagonist. It is used for the prevention and treatment of nausea and vomiting caused by chemotherapy and surgery. Oral administration in combination with palonosetron.

On latest update relevant data on breastfeeding was not found.

Its very high volume of distribution, and its very high plasma protein binding make excretion into breast milk unlikely.

Side effects are few and usually mild.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.


  • Metoclopramide (Safe substance and/or breastfeeding is the best option.)
  • Ondansetron (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Netupitant in other languages or writings:


Netupitant belongs to these groups or families:


Main tradenames from several countries containing Netupitant in its composition:

  • Akynzeo™. Contains other elements than Netupitant in its composition


Variable Value Unit
Oral Bioavail. 60 %
Molecular weight 579 daltons
Protein Binding 99.5 %
VD 28.3 ± 12.9 l/Kg
Tmax 5 (3 - 6) hours
96 hours


  1. EMA. Akynzeo. Ficha técnica. 2020 Full text (in our servers)
  2. Purdue. Akynzeo. Drug Summary. 2017 Full text (in our servers)

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