Last update Aug. 19, 2021

νάτριο χρυσοθειομηλεϊνικό

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Gold compound with anti-inflammatory properties. Other similar compounds are aurothioglucose and auranofin.
Used as a disease-modifying antirheumatic drug (DMARD) in progressive rheumatoid arthritis and psoriatic arthritis.
Intramuscular administration every 1 to 4-6 weeks.

Aurothiomalate and aurothioglucose are excreted in breast milk in small amounts (Bennett 1990, Rooney 1987, Bell 1976, Sorensen 1970) but this could be clinically significant (Bennett 1990, Blau 1973).

No problems have been observed in infants whose mothers took aurothiomalate (Bennett 1990, Bell 1976). A girl around 18 months of age developed transient facial edema 3 months after the mother’s treatment with aurothiomalate was discontinued (Bell 1976).
The plasma or urine levels of said infants were undetectable or very low (Rooney 1987, Bell 1976), 6 to 22 times lower than maternal serum levels (Bennett 1990).

Expert authors consider the use of gold salts during lactation to be low risk (Ostensen 1992, Needs 1985). Other authors believe that they best be avoided during breastfeeding (Janssen 2000, Byron 1987, Ostensen 1986).
American Academy of Pediatrics: Gold salts are medications usually compatible with breastfeeding (AAP 2001).


See below the information of this related product:

  • Auranofin (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
DONATE NOW

Other names

νάτριο χρυσοθειομηλεϊνικό is Aurothiomalate Sodium in Greek.

Is written in other languages:

νάτριο χρυσοθειομηλεϊνικό is also known as

Group

νάτριο χρυσοθειομηλεϊνικό belongs to this group or family:

Tradenames

Main tradenames from several countries containing νάτριο χρυσοθειομηλεϊνικό in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 25 %
Molecular weight 391 daltons
Protein Binding 85 - 95 %
VD 0.26 l/Kg
pKa 3.18 -
Tmax 3 - 6 hours
T½ 300 hours
M/P ratio 0.01 - 0.3 -
Theoretical Dose 0.002 - 0.014 mg/Kg/d
Relative Dose 33 %
Ped.Relat.Dose 10 - 20 %

References

  1. Janssen NM, Genta MS. The effects of immunosuppressive and anti-inflammatory medications on fertility, pregnancy, and lactation. Arch Intern Med. 2000 Abstract Full text (link to original source) Full text (in our servers)
  2. Ostensen M. Treatment with immunosuppressive and disease modifying drugs during pregnancy and lactation. Am J Reprod Immunol. 1992 Abstract
  3. Bennett PN, Humphries SJ, Osborne JP, Clarke AK, Taylor A. Use of sodium aurothiomalate during lactation. Br J Clin Pharmacol. 1990 Jun;29(6):777-9. Abstract Full text (link to original source) Full text (in our servers)
  4. Rooney TW, Lorber A, Veng-Pedersen P, Herman RA, Meehan R, Hade J, Hade A, Furst DE. Gold pharmacokinetics in breast milk and serum of a lactating woman. J Rheumatol. 1987 Dec;14(6):1120-2. Abstract
  5. Ostensen M, Skavdal K, Myklebust G, Tomassen Y, Aarbakke J. Excretion of gold into human breast milk. Eur J Clin Pharmacol. 1986;31(2):251-2. Abstract
  6. Needs CJ, Brooks PM. Antirheumatic medication during lactation. Br J Rheumatol. 1985 Abstract
  7. Bell RA, Dale IM. Gold secretion in maternal milk. Arthritis Rheum. 1976 Nov-Dec;19(6):1374. No abstract available. Abstract
  8. Blau SP. Letter: Metabolism of gold during lactation. Arthritis Rheum. 1973 Nov-Dec;16(6):777-8. No abstract available. Abstract

Total visits

1,108

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM