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Nabilone, a synthetic cannabinoid structurally similar to delta-9-THC in cannabis, has antiemetic properties and is used for the control of nausea and vomiting associated with cancer chemotherapy in patients who have not responded adequately to conventional antiemetics (Martindale). Also in anorexia and weight loss in patients with HIV (DrugBank). Oral administration in two to three daily doses.
Since the last update we have not found published data on its excretion in breastmilk.
Its pharmacokinetic data (very high percentage of protein binding, and very wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.
The elimination half-life of nabilone is 2 hours; that of its metabolites, which are unknown if they are active, of 35 hours. (Martindale)
Nabilone does not alter plasma levels of prolactin. (Mendelson 1984)
A punctual use or at the minimum effective dose could be compatible with breastfeeding by monitoring the infant's neurological and feeding status.
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.