Last update Oct. 29, 2024

ميبيرامين

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

1st generation antihistamine, derived from ethylenediamine, with important sedative and antimuscarinic effects. It is used orally for the symptomatic treatment of cough and common cold and as hypnotic in insomnia. As a skin cream it is used for insect bites and pruritus.

At the time of the last update, we did not find published data on its excretion in breast milk.

Drug with little bibliographic support and marketed in very few countries. Component of many “over-the-counter” drugs in polyassociation with expectorants, bronchodilators, antitussives, etc. It is advisable to avoid drug associations, especially during lactation.

It has an antiprolactin effect that could inhibit lactation in the first weeks after delivery.

Although its occasional and moderate use during lactation is probably safe, until more published data on this drug in relation to lactation is known, safer alternatives are preferable.

Topical use as a dermatological preparation is safe during lactation. Do not apply to the breast.

Monitor drowsiness and adequate feeding of the infant.

Due to its sedative effect, bed sharing with the infant is not recommended if this drug is being taken. (UNICEF 2018, 2017, 2017, 2014, 2014, 2013 and 2006, Landa 2012, ABM 2008)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

ميبيرامين is Mepyramine in Arabic.

Is written in other languages:

ميبيرامين is also known as

Tradenames

Main tradenames from several countries containing ميبيرامين in its composition:

  • Antemesyl
  • Anthisan
  • Antigrippine (Portugal)™. Contains other elements than ميبيرامين in its composition
  • Antigrippine (Netherlands)™. Contains other elements than ميبيرامين in its composition
  • Calamycin™. Contains other elements than ميبيرامين in its composition
  • Conidrin™. Contains other elements than ميبيرامين in its composition
  • Drynisan™. Contains other elements than ميبيرامين in its composition
  • Fluidasa (Spain)
  • Gripanil C™. Contains other elements than ميبيرامين in its composition
  • Lentostamin™. Contains other elements than ميبيرامين in its composition
  • Midol Menstrual Complete™. Contains other elements than ميبيرامين in its composition
  • Neo-Diophen™. Contains other elements than ميبيرامين in its composition
  • Nicaina™. Contains other elements than ميبيرامين in its composition
  • Pinazo™. Contains other elements than ميبيرامين in its composition
  • Poly Hist DHC™. Contains other elements than ميبيرامين in its composition
  • Tussplex™. Contains other elements than ميبيرامين in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 285 daltons
Tmax 2 - 4 hours
3 - 3.5 hours

References

  1. UNICEF UK. Caring for your baby at night. A guide for parents. 2018 Full text (link to original source) Full text (in our servers)
  2. UNICEF. Ball H, Blair PS. (For UNICEF UK). Caring for your baby at night. Health professional´s guide. 2017 Full text (link to original source) Full text (in our servers)
  3. UNICEF UK. Statement on co-sleeping following publication of new NICE postnatal guidance. Infosheet. 2014 Full text (link to original source) Full text (in our servers)
  4. UNICEF UK Baby Friendly Initiative statement on Bed-sharing when parents do not smoke: is there a risk of SIDS? An individual level analysis of five major case-control studies. None 2013 Full text (link to original source) Full text (in our servers)
  5. L.Landa Rivera, M.Díaz-Gómez, A.Gómez Papi, J.M.Paricio Talayero, C.Pallás Alonso, M.T.Hernández Aguilar, J.Aguayo Maldonado, J.M.Arena Ansotegui, S.Ares Segura, A.Jiménez Moya, J.J.Lasarte Velillas, J.Martín Calama, M.D.Romero Escós. El colecho favorece la práctica de la lactancia materna y no aumenta el riesgo de muerte súbita del lactante. Dormir con los padres. Rev Pediatr Aten Primaria. 14:53-60 2012 Full text (link to original source) Full text (in our servers)
  6. So M, Bozzo P, Inoue M, Einarson A. Safety of antihistamines during pregnancy and lactation. Can Fam Physician. 2010 May;56(5):427-9. Abstract Full text (link to original source) Full text (in our servers)
  7. ABM - Comité de protocolos de la Academia médica de lactancia materna (Academy of Breastfeeding Medicine). Protocolo Clínico de la ABM #6: Lineamientos sobre la práctica de dormir al bebé junto con la madre y la lactancia materna Revisión, marzo de 2008. Breastfeeding Medicine 2008 Full text (link to original source) Full text (in our servers)
  8. ABM - The Academy of Breastfeeding Medicine Protocol Committee. ABM Clinical Protocol #6: Guideline on Co-Sleeping and Breastfeeding. Breastfeeding Medicine 2008 Abstract Full text (link to original source) Full text (in our servers)
  9. AEMPS. Mepifilina. Ficha técnica. 2007 Full text (in our servers)
  10. Leimgruber A. [Treatment of asthma and rhinitis during pregnancy and breast feeding]. Rev Med Suisse. 2007 Abstract
  11. UNICEF UK. Compartiendo la cama con tu bebé. Guía para madres que amamantan. Folleto 2006 Full text (in our servers)
  12. Solhaug V, Roland PD. Bruk av antihistaminer under graviditet og amming \ [Use of antihistaminics during pregnancy and breast feeding]. Tidsskr Nor Laegeforen. 2004 Abstract Full text (link to original source) Full text (in our servers)
  13. Buhimschi CS. Endocrinology of lactation. Obstet Gynecol Clin North Am. 2004 Abstract
  14. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  15. Messinis IE, Souvatzoglou A, Fais N, Lolis D. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985 Apr;8(2):143-6. Abstract
  16. Pontiroli AE, De Castro e Silva E, Mazzoleni F, Alberetto M, Baio G, Pellicciotta G, De Pasqua A, Stella L, Girardi AM, Pozza G. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981 Abstract

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