Last update Sept. 16, 2022

Mizolastine

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Mizolastine is a second-generation, non-sedating antihistamine without significant antimuscarinic actions that is used to treat the symptoms of allergic rhinoconjunctivitis and urticaria. oral administration.

Since the last update we have not found published data on its excretion in breastmilk.

Its pharmacokinetic data (very high percentage of protein binding and very wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Mizolastine in other languages or writings:

Group

Mizolastine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Mizolastine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 65 %
Molecular weight 433 daltons
Protein Binding 98.4 %
VD 1.4 l/Kg
pKa 8.08 -
Tmax 1.5 hours
13 hours

References

  1. Electronic medicines compendium (emc) MIzollen (Mizolastine). Drug Summary. 2022 Consulted on Sept. 16, 2022 Full text (link to original source)
  2. AEMPS. Mizolastina. Ficha técnica. 2019 Full text (in our servers)
  3. del Cuvillo A, Mullol J, Bartra J, Dávila I, Jáuregui I, Montoro J, Sastre J, Valero AL. Comparative pharmacology of the H1 antihistamines. J Investig Allergol Clin Immunol. 2006;16 Suppl 1:3-12. Review. No abstract available. Abstract Full text (link to original source) Full text (in our servers)

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