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Antibacterial of the tetracycline group with similar properties and uses to tetracycline.
Prescribed for urinary, skin and respiratory infections and for the treatment of acne.
Oral administration of two daily doses.
Excreted in small and not clinically significant amounts in breast milk (Fulton 1992, Mizuno 1969). Being more liposoluble than other tetracyclines, excretion in breast milk is somewhat higher.
Intestinal absorption of tetracyclines is greatly diminished in lactating infants due to the formation of non-absorbable chelates with milk calcium (Pfizer 2015, Sandoz 2013, Mitrano 2009, Chin 2001). Doxycycline and minocycline have less affinity for calcium (Sandoz 2013), so they would not be of choice during lactation.
It should be considered the possibility of negative cultures in febrile infants as well as the possibility of gastroenteritis due to intestinal microbiome alterations in lactating infants of mothers who take antibiotics (Ito 1993).
it can transiently stain breast milk and other body fluids black (Sandoz 2013, Eisen 1998, Hunt 1996, Basler 1985).
Its prolonged used is not advisable because it may affect dental coloration, growth cartilage and intestinal flora of the infant (Pfizer 2015).
Until we have more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in the case of prematurity.