Last update Aug. 29, 2021

Methylsulphonylmethane (MSM)

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Methylsulfonylmethane (MSM) is an organosulfur compound, a product of the oxidation of dimethylsulfoxide (DMSO). Found naturally in plants, animals, and humans (MedlinePlus 2020).
It is used, without clear evidence of its efficacy (Liu 2021, Notarnicola 2011, Brien 2011) in the treatment of osteoarticular pain and as a nutritional supplement. It is also used as a solvent in industry.
Oral or topical cutaneous administration.

At the date of the last update, there was no available published data on its excretion in breast milk.

The scarce available pharmacokinetic data about it does not allow prediction on its excretion in breast milk.

Given the null published toxicity, moderate use would be compatible with breastfeeding.

See below the information of this related product:

  • Dimethyl Sulfoxide (DMSO) (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)


We do not have alternatives for Methylsulphonylmethane (MSM).

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Methylsulphonylmethane (MSM) is also known as

Methylsulphonylmethane (MSM) in other languages or writings:


Main tradenames from several countries containing Methylsulphonylmethane (MSM) in its composition:

  • Aim Frame Essentials™. Contains other elements than Methylsulphonylmethane (MSM) in its composition
  • Joint-Pro™. Contains other elements than Methylsulphonylmethane (MSM) in its composition


Variable Value Unit
Molecular weight 94 daltons


  1. Liu X, Robbins S, Eyles J, Fedorova T, Virk S, Deveza LA, McLachlan AJ, Hunter DJ. Efficacy and safety of a supplement combination on hand pain among people with symptomatic hand osteoarthritis an internet-based, randomised clinical trial the RADIANT study. Osteoarthritis Cartilage. 2021 Feb 19. pii: S1063-4584(21)00436-2. Abstract
  2. MedlinePlus. Metilsulfonilmetano (MSM). Información de salud para usted. 2020 Full text (link to original source) Full text (in our servers)
  3. MedlinePlus. Methylsulfonylmethane (MSM). Trusted Health information for you. 2020 Full text (link to original source) Full text (in our servers)
  4. Notarnicola A, Tafuri S, Fusaro L, Moretti L, Pesce V, Moretti B. The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis. Adv Ther. 2011 Oct;28(10):894-906. Abstract
  5. Brien S, Prescott P, Lewith G. Meta-analysis of the related nutritional supplements dimethyl sulfoxide and methylsulfonylmethane in the treatment of osteoarthritis of the knee. Evid Based Complement Alternat Med. 2011;2011:528403. Abstract

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