Last update June 10, 2018



Safe substance and/or breastfeeding is the best option.

Methyl methacrylate (MMA) forms the basis of acrylic bone cements used in orthopedic surgery and also in dental repairs and intraocular lenses.

During its preparation, generally in the operating room, there may be exposure to vapours which irritate the respiratory tract, eyes and skin, without the ability to gauge significant toxic effects with acute exposure (Muttray 2015), nor measure detectable levels in the plasma (Homlar 2013 ) or breastmilk (Linehan 2006) of the personnel who are exposed.

The threshold limit values ​​for daily exposure of 50 ppm (208 mg/m3) and the threshold limit values ​​for short-term exposure of 100 ppm (416 mg/m3) (Muttray 2015, Rosell 2008), are difficult to reach if adequate protection systems are used (Downes 2014, Rosell 2008). Most exposed is the person who prepares the cement.
Exposure is minimized by ventilation systems, use of double gloves, goggles and respiratory masks with an adequate filter and, above all, by the use of closed preparation systems (Downes 2014, Rosell 2008).

Very low levels of MMA have been measured in breastmilk after an arthroplasty with methylmethacrylate was performed on a breastfeeding mother, so it would not be necessary to interrupt breastfeeding (Hersh 1995).


We do not have alternatives for Methylmethacrylate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Methylmethacrylate is also known as

Methylmethacrylate in other languages or writings:


Methylmethacrylate belongs to this group or family:


Main tradenames from several countries containing Methylmethacrylate in its composition:


Variable Value Unit
Molecular weight 100 daltons


  1. Muttray A, Gosepath J, Brieger J, Faldum A, Zagar C, Mayer-Popken O, Jung D, Roßbach B, Mann W, Letzel S. No acute effects of an exposure to 50 ppm methyl methacrylate on the upper airways. Int Arch Occup Environ Health. 2015 Abstract
  2. Downes J, Rauk PN, Vanheest AE. Occupational hazards for pregnant or lactating women in the orthopaedic operating room. J Am Acad Orthop Surg. 2014 Abstract
  3. Homlar KC, Sellers MH, Halpern JL, Seeley EH, Holt GE. Serum levels of methyl methacrylate following inhalational exposure to polymethylmethacrylate bone cement. J Arthroplasty. 2013 Abstract
  4. Wright. Cemento Óseo Orthoset. Ficha técnica 2012 Full text (in our servers)
  5. Rosell Farrás MG, Méndez Liz MJ. Cementos óseos: prevención de la exposición a sus componentes durante su preparación. Notas Técnicas de prevención. 2008 Full text (link to original source) Full text (in our servers)
  6. Linehan CM, Gioe TJ. Serum and breast milk levels of methylmethacrylate following surgeon exposure during arthroplasty. J Bone Joint Surg Am. 2006 Abstract
  7. Hersh J, Bono JV, Padgett DE, Mancuso CA. Methyl methacrylate levels in the breast milk of a patient after total hip arthroplasty. J Arthroplasty. 1995 Abstract

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