Last update Feb. 11, 2019

Methenamine Mandelate

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

An antibacterial used in the long-term prophylaxis and treatment of recurrent lower urinary tract infections (bladder) and asymptomatic bacteriuria.
Oral administration 2 to 4 times a day.

It is excreted in breastmilk in clinically insignificant amounts and no problems have been observed in infants whose mothers were taking it (Allgen 1979).

Several expert authors consider it safe or probably safe to use this medication during breastfeeding (Lactmed 2018, Hale 2017 p 624, Briggs 2017).

Exposure can be minimized by waiting to breastfeed three hours after taking the drug (Mactal 2001).

Alternatives

We do not have alternatives for Methenamine Mandelate.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Methenamine Mandelate is also known as Methenamine. Here it is a list of alternative known names::


Methenamine Mandelate in other languages or writings:

Group

Methenamine Mandelate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Methenamine Mandelate in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 140 daltons
Tmax 1 - 2 hours
T½ 3 - 4 hours
M/P ratio 1 -
Theoretical Dose 0.65 - 1.37 mg/Kg/d
Relative Dose 3.9 - 8.2 %

References

  1. LactMed. Methenamine. Drugs and Lactation Database. 2018 Abstract
  2. Hale TW, Rowe HE. Medications & Mothers' Milk. A Manual of Lactation Pharmacology. Springer Publishing Company. 2017
  3. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  4. Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001 Abstract
  5. Allgén LG, Holmberg G, Persson B, Sörbo B. Biological fate of methenamine in man. Absorption, renal excretion and passage to umbilical cord blood, amniotic fluid and breast milk. Acta Obstet Gynecol Scand. 1979 Abstract

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