Last update July 24, 2014


High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

Although it is secreted into breast milk it has not been detected in infant’s blood because it forms non absorbable chelate compounds with milk calcium. It is not convenient a prolonged use (more than 3-4 weeks) for a potential damage on bone growth plates, teeth discoloration, or alteration of intestinal flora. Be aware of the possibility of false negative results of bacterial cultures when the mother is on antibiotics.
Not commercially available in Spain


  • Tetracycline ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.


Metacycline-Hcl belongs to this group or family:


Main tradenames from several countries containing Metacycline-Hcl in its composition:


Variable Value Unit
Oral Bioavail. 58 %
Molecular weight 479 daltons
Protein Binding 80 %
Tmax 3 hours
15 hours
M/P ratio 0.5 -


  1. Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001 Feb;17(1):54-65. Abstract

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