Last update June 28, 2022

Memantine Hydrochloride

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

It is a derivative of amantadine. It is used in the treatment of Alzheimer's disease, parkinsonism and central spasticity and other brain injuries or comatose states. Oral administration once or twice daily.

Since the last update we have not found published data on its excretion in breastmilk.

Its low molecular weight and low binding to plasma proteins would facilitate its excretion in breast milk, while its high volume of distribution would make it difficult.

For some authors it is an expendable product, with a negative risk/benefit ratio. (Prescrire 2018)

It may cause drowsiness, dizziness, hypertension, dyspnea, constipation, headache, and liver function abnormalities. (AEMPS 2020)


We do not have alternatives for Memantine Hydrochloride.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Memantine Hydrochloride in other languages or writings:


Memantine Hydrochloride belongs to this group or family:


Main tradenames from several countries containing Memantine Hydrochloride in its composition:


Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 179 daltons
Protein Binding 45 %
VD 10 l/Kg
pKa 10.7 -
Tmax 3 - 8 hours
60 - 100 hours


  1. AEMPS. Memantina. Ficha técnica. 2020 Full text (in our servers)
  2. Redaction Prescrire. Pour mieux soigner, des médicaments à écarter : bilan 2018. 2018 Full text (link to original source) Full text (in our servers)
  3. Sandoz. Memantine. Drug Summary. 2015 Full text (in our servers)

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