Last update Dec. 20, 2023
Compatible
We do not have alternatives for Mannitol since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Mannitol is also known as
Mannitol in other languages or writings:
Main tradenames from several countries containing Mannitol in its composition:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 7 - 17 | % |
Molecular weight | 182 | daltons |
VD | 0.49 | l/Kg |
pKa | 12.59 | - |
T½ | 1.2 ± 0.5 | hours |
Write us at elactancia.org@gmail.com
e-lactancia is a resource recommended by La Liga de la Leche, España of Spain
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Mannitol is an alcohol of the monosaccharide sugar mannose found naturally in fruits and vegetables. It is used as an osmotic diuretic to reduce intracranial and intraocular pressure, measure glomerular filtration rate, detect asthma and control pulmonary symptoms associated with cystic fibrosis. Intravenous administration. It is also used orally as an osmotic laxative due to its lack of intestinal absorption and as a food sweetener (E421).
At the time of the last update, we found no published data on its excretion in breast milk.
Its low oral bioavailability makes it difficult to pass into maternal plasma and, therefore, into breast milk, as well as into the infant's plasma from ingested breast milk, except in premature infants and the immediate neonatal period in which there may be greater intestinal permeability.
It is a metabolically inert product in humans that is eliminated unchanged in the urine before any metabolism can take place.
It is believed that it does not readily enter the cellular compartment, so it would not enter lactocytes and will not pass into milk except during the initial period of lactogenesis through the spaces between lactocytes. (Hale).
Expert authors consider it probably compatible with lactation. (Hale, Briggs 2015)
Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs: compatible with Breastfeeding. (WHO 2002)