Last update June 14, 2022

Loxapine

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Antipsychotic used in the treatment of schizophrenia and bipolar disorder. Oral, intramuscular or inhaled administration.

Since the last update we have not found published data on its excretion in breastmilk.

Its high percentage of protein binding make it highly unlikely that significant quantities will pass into breast milk.

It can cause increased levels of prolactin. (Hellings 2015, Robertson 1982)

Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in cases of prematurity.


See below the information of this related product:

Alternatives

  • Aripiprazole (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Olanzapine (Safe substance and/or breastfeeding is the best option.)
  • Quetiapine Fumarate (Safe substance and/or breastfeeding is the best option.)
  • Risperidone (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Loxapine is also known as


Loxapine in other languages or writings:

Groups

Loxapine belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Loxapine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 33 %
Molecular weight 328 daltons
Protein Binding 97 %
pKa 7.2 -
Tmax 1 - 2; inhal: 0.03 hours
T½ 4 - 19 hours

References

  1. Apotex. Loxapine. Drug Summary. 2021 Full text (in our servers)
  2. Hellings JA, Reed G, Cain SE, Zhou X, Barth FX, Aman MG, Palaguachi GI, Mikhnev D, Teng R, Andridge R, Logan M, Butler MG, Han JC. Loxapine add-on for adolescents and adults with autism spectrum disorders and irritability. J Child Adolesc Psychopharmacol. 2015 Mar;25(2):150-9. Abstract
  3. EMA. Loxapina (Adasuve). Ficha técnica. 2013 Full text (in our servers)
  4. Robertson AG, Berry R, Meltzer HY. Prolactin stimulating effects of amoxapine and loxapine in psychiatric patients. Psychopharmacology (Berl). 1982 Abstract

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