Last update March 22, 2018

Loperamide Hydrochloride

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Opioid drug derived from pethidine.
Contraindicated for those children younger than 2 year old.
Indiscriminate use for treatment of gastroenteritis is not justified. Most acute diarrheic disorders are self-limijted conditions. WHO’s Oral Rehydration Solutions and appropriate nutritional support are recommended.

Excreted into breast milk in non-significant levels. Its low oral bioavailability makes it difficult to acceed the infant serum.

American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001).


We do not have alternatives for Loperamide Hydrochloride since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Loperamide Hydrochloride is also known as

Loperamide Hydrochloride in other languages or writings:


Main tradenames from several countries containing Loperamide Hydrochloride in its composition:


Variable Value Unit
Oral Bioavail. 0.3 %
Molecular weight 477 daltons
Protein Binding 97 %
Tmax 4 - 5 hours
T1/2 11 hours
M/P ratio 0.4 -
Theoretical Dose 0.00004 mg/Kg/d
Relative Dose 0.02 %
Ped.Relat.Dose 0.01 %


  1. Cabo-Lopez I, Canneti B, Puy-Nunez A. Epilepsia y lactancia materna: del mito a la realidad. [Epilepsy and breastfeeding: from myth to reality]. Rev Neurol. 2019 Jul 16;69(2):68-76. Abstract
  2. Regnard C, Twycross R, Mihalyo M, Wilcock A. Loperamide. J Pain Symptom Manage. 2011 Abstract Full text (in our servers)
  3. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010 Jan-Feb;17(1):32-47. Abstract Full text (link to original source) Full text (in our servers)
  4. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)
  5. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  6. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000 Nov;16(4):319-31. Review. Erratum in: J Hum Lact 2001 Feb;17(1):90. Abstract
  7. Hagemann TM. Gastrointestinal medications and breastfeeding. J Hum Lact. 1998 Sep;14(3):259-62. Review. Abstract
  8. Nikodem VC, Hofmeyr GJ. Secretion of the antidiarrhoeal agent loperamide oxide in breast milk. Eur J Clin Pharmacol. 1992 Abstract

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e-lactancia is a resource recommended by Confederación Nacional de Pediatría (CONAPEME) of Mexico

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