Last update April 24, 2025

Lincomycin; Lincomycin Hydrochloride

Compatible

Safe product and/or breastfeeding is the best option.

Lincosamide antibacterial structurally similar to clindamycin. Oral, intramuscular or intravenous administration 2-4 times daily.

Like clindamycin, it is excreted in breast milk in clinically insignificant amount (Medina 1963).

Its low oral bioavailability, which also decreases with simultaneous ingestion of food, makes it difficult for it to pass into the infant's plasma from ingested breast milk, except in premature infants and the immediate neonatal period, where there may be greater intestinal permeability.

Expert authors consider it compatible with breastfeeding (Hale, Briggs 2015, Schaefer 2015, Amir 2011). 

In infants whose mothers take antibiotics, alteration of the intestinal flora may occur (Ito 1993).

Alternatives

  • Clindamycin (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
DONATE NOW

Other names

Lincomycin; Lincomycin Hydrochloride in other languages or writings:

Group

Lincomycin; Lincomycin Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Lincomycin; Lincomycin Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 20 - 35 %
Molecular weight 407 daltons
Protein Binding 72 %
VD 0.9 - 1.5 l/Kg
pKa 12.37 -
Tmax 2 - 4 hours
T½ 5 hours
M/P ratio 0.2 - 0.9 -
Theoretical Dose 0.19 mg/Kg/d
Relative Dose 0. 6 - 0. 8 %
Ped.Relat.Dose 1 - 2 %

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  2. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, Third Edition. 2015
  3. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  4. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011 Sep;40(9):684-90. Review. Abstract
  5. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  6. Stéen B, Rane A. Clindamycin passage into human milk. Br J Clin Pharmacol. 1982 Abstract Full text (link to original source) Full text (in our servers)
  7. Wilson JT. Milk/plasma ratios and contraindicated drugs. In: Wilson JT, ed. Drugs in Breast Milk. Balgowlah, Australia: ADIS Press: 78–9. 1981
  8. MEDINA A, FISKE N, HJELT-HARVEY I, BROWN CD, PRIGOT A. ABSORPTION, DIFFUSION, AND EXCRETION OF A NEW ANTIBIOTIC, LINCOMYCIN. Antimicrob Agents Chemother (Bethesda). 1963 Abstract

Total visits

74,143

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM