Last update July 26, 2024

Lenacapavir, Lenacapavir Sodium (LEN)

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Lenacapavir is an HIV-1 capsid inhibitor with antiviral activity against HIV-1. It is used with other antiretrovirals for the treatment of multidrug-resistant HIV-1 infection. Oral or subcutaneous administration. It has been approved in 2022 by the EMA and FDA.

At the time of the last update, we found no published data on its excretion in breast milk.

Its pharmacokinetic data (high molecular weight, very high percentage of binding to plasma proteins and very large volume of distribution) make it unlikely to pass into breast milk in clinically significant quantities.

Its low oral bioavailability makes it difficult for it to pass into infant plasma from ingested breast milk, except in premature infants and the immediate neonatal period in which there may be greater intestinal permeability.

"Individuals with HIV who are on ART with a sustained undetectable viral load and who choose to breastfeed should be supported in this decision". (Panel 2023 E-11)

 

 


See below the information of this related product:

Alternatives

We do not have alternatives for Lenacapavir, Lenacapavir Sodium (LEN).

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Lenacapavir, Lenacapavir Sodium (LEN) in other languages or writings:

  • ليناكابافير (Arabic)
  • Ленакапавир (Cyrillic)
  • 来那帕韦 (Chinese)
  • N-[(1S)-1-{3-[4-Chloro-3-(methanesulfonamido)-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl]-6-[3-(methanesulfonyl)-3-methylbut-1-yn-1-yl]pyridin-2-yl}-2-(3,5-difluorophenyl)ethyl]-2- [(3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl]acetamide (Chemical name)
  • C39H32ClF10N7O5S2 (Molecular formula)
  • J05AX31 (ATC Code/s)

Group

Lenacapavir, Lenacapavir Sodium (LEN) belongs to this group or family:

Tradenames

Main tradenames from several countries containing Lenacapavir, Lenacapavir Sodium (LEN) in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 6 - 10 %
Molecular weight 968 daltons
Protein Binding 99.8 %
VD 13.9 l/Kg
pKa 6.69 -
Tmax 4 hours
240 - 288 hours

References

We are working to add the scientific references of this product. It will be available soon. If you wish to have access to this information, please let us know by leaving your comment in the opinion section below.

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e-lactancia is a resource recommended by La Liga de la Leche, España of Spain

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