Last update May 1, 2022
Lansoprazole is a proton pump inhibitor (PPI) with actions and uses similar to those of omeprazole. It is indicated in the treatment of peptic ulcer and gastroesophageal reflux. Oral administration once daily.
At latest update, relevant information on excretion into breast milk was not found.
Its pharmacokinetic data (very high percentage of protein binding, very wide volume of distribution and short half-life) make it highly unlikely that significant quantities will pass into breast milk.
Both Omeprazole and Pantoprazole, from the same pharmacological group (PPI) and with similar pharmacokinetic characteristics, are excreted in insignificant amounts in breast milk.
Since it's neutralized by the acid pH of stomach, capsules with enteric coated granules are used. Because of this, it is thought that the small quantity of Lansoprazole that may reach the breast milk would be neutralized by infant's stomach. In addition, absorption is greatly decreased by the presence of food.
It is a medication used in neonates and young infants. (AEP 2020)
Hyperprolactinemia and galactorrhea have been reported by the use of such medication (Duwicquet 2017, Jabbar 2010, Izquierdo 2004), though some authors have failed to show the same findings. (Dammann 1994 &1993)
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.
Thank you for helping to protect and promote breastfeeding.
e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM