Last update May 14, 2024

Lansoprazole

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Lansoprazole is a proton pump inhibitor (PPI) with actions and uses similar to those of omeprazole. It is indicated in the treatment of peptic ulcer and gastroesophageal reflux. Oral administration once daily.

At latest update, relevant information on excretion into breast milk was not found.

Its pharmacokinetic data (very high percentage of protein binding, very wide volume of distribution and short half-life) make it highly unlikely that significant quantities will pass into breast milk.

Both Omeprazole and Pantoprazole, from the same pharmacological group (PPI) and with similar pharmacokinetic characteristics, are excreted in insignificant amounts in breast milk.

Since it's neutralized by the acid pH of stomach, capsules with enteric coated granules are used. Because of this, it is thought that the small quantity of Lansoprazole that may reach the breast milk would be neutralized by infant's stomach. In addition, absorption is greatly decreased by the presence of food. 

It is a medication used in neonates and young infants. (AEP 2020)

Hyperprolactinemia and galactorrhea have been reported by the use of such medication (Duwicquet 2017, Jabbar 2010, Izquierdo 2004), though some authors have failed to show the same findings. (Dammann 1994 &1993)

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

  • Famotidine (Safe substance and/or breastfeeding is the best option.)
  • Nizatidine (Safe substance and/or breastfeeding is the best option.)
  • Omeprazole (Safe substance and/or breastfeeding is the best option.)
  • Pantoprazole (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Lansoprazole in other languages or writings:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 80 %
Molecular weight 369 daltons
Protein Binding 97 %
VD 0.4 - 0.5 l/Kg
pKa 9.35 -
Tmax 1.5 - 2 hours
1 - 2 hours

References

  1. Ashfaq M, Haroon MZ, Alkahraman YM. Proton pump inhibitors therapy and risk of hyperprolactinemia with associated sexual disorders. Endocr Regul. 2022 Apr 30;56(2):134-147. Abstract Full text (link to original source)
  2. AEP. Comité de Medicamentos de la Asociación Española de Pediatría. Lansoprazol Pediamecum 2020 Full text (link to original source) Full text (in our servers)
  3. Duwicquet F, Gras-Champel V, Masmoudi K. [Hyperprolactinemia with galactorrhea induced by lansoprazole: A case report]. Therapie. 2017 Dec;72(6):691-693. Abstract
  4. Jabbar A, Khan R, Farrukh SN. Hyperprolactinaemia induced by proton pump inhibitor. J Pak Med Assoc. 2010 Abstract Full text (link to original source)
  5. Izquierdo Prieto OM, Moreno Alía E, Rosillo González A. [Galactorrhea induced by lansoprazole]. Aten Primaria. 2004 Abstract
  6. Dammann HG, Bethke T, Burkhardt F, Wolf N, Khalil H, Luehmann R. Effects of pantoprazole on endocrine function in healthy male volunteers. Aliment Pharmacol Ther. 1994 Abstract
  7. Dammann HG, von zur Mühlen A, Balks HJ, Damaschke A, Steinhoff J, Hennig U, Schwarz JA, Fuchs W. The effects of lansoprazole, 30 or 60 mg daily, on intragastric pH and on endocrine function in healthy volunteers. Aliment Pharmacol Ther. 1993 Abstract

Total visits

83,036

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by El Parto Es Nuestro of Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM