Last update April 27, 2024

Колестипола

Compatible

Safe substance and/or breastfeeding is the best option.

High molecular weight resin-polymer similar in action to cholesteramine. It prevents the normal reabsorption of bile acids and forces the liver to produce more bile, thus reducing the body's cholesterol levels (especially LDL), since cholesterol is a major component of bile. Oral administration once or twice a day. 

At the time of the last update, we did not find any published data regarding lactation. 

The intestinal absorption of the drug is null (AEMPS 2016, Pfizer 2013), so it cannot pass into breast milk, nor would it pass into the infant's plasma from ingested breast milk. 

Its high molecular weight makes it very unlikely to pass significant amounts into breast milk. It is unlikely to alter the lipid composition of milk. 

Prolonged use may cause plasma deficiency, due to lack of absorption, of fat-soluble vitamins (A, D, E, K), so it may be advisable to supplement to avoid deficiency of these vitamins in breast milk. 

Several experts and expert consensuses consider safe or probably safe the use of this medication during breastfeeding. (Hale, LactMed, Lawrence 2016 p393, Serrano 2015, Briggs 2015)

It is advisable to follow a lipid-lowering diet and to engage in regular daily physical activity, at least half an hour daily.

For considerations on the appropriateness of lipid-lowering treatment during breastfeeding see Maternal hyperlipidemia, hypercholesterolemia, hypertriglyceridemia.


See below the information of this related product:

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Колестипола is Colestipol Hydrochloride in Cyrillic.

Is written in other languages:

Group

Колестипола belongs to this group or family:

Tradenames

Main tradenames from several countries containing Колестипола in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight muy alto / very high daltons
pKa 15.1 -

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. AEMPS. Colestipol. Ficha técnica. 2016 Full text (in our servers)
  4. Lawrence RA, Lawrence RM. Breastfeeding. A guide for the medical profession. Eighth Edition. Philadelphia: Elsevier; 2016
  5. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  6. Serrano Aguayo P, García de Quirós Muñoz JM, Bretón Lesmes I, Cózar León MV. Tratamiento de enfermedades endocrinológicas durante la lactancia. [Endocrinologic diseases management during breastfeeding.] Med Clin (Barc). 2015 Jan 20;144(2):73-9. Abstract
  7. Pfizer. Colestipol Drug Summary. 2013 Full text (in our servers)

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