Last update Oct. 23, 2023
Limited compatibility
We do not have alternatives for カベルゴリン.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Thank you for helping to protect and promote breastfeeding.
カベルゴリン is Cabergoline in Japanese.
Is written in other languages:カベルゴリン belongs to these groups or families:
Main tradenames from several countries containing カベルゴリン in its composition:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 100 | % |
Molecular weight | 452 | daltons |
Protein Binding | 41 | % |
pKa | 15.25 | - |
Tmax | 2 - 3 | hours |
T½ | 63 - 69 | hours |
Write us at elactancia.org@gmail.com
e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Cabergoline, a derivative of ergot, is a dopamine D2 agonist with actions and uses similar to those of bromocriptine. It potently inhibits prolactin secretion. It is used in the treatment of disorders associated with hyperprolactinemia, in the treatment of Parkinson's disease and to suppress puerperal lactation. To inhibit lactogenesis II (milk let-down) a single dose (0.5 - 1 mg) on the first day after delivery is sufficient. To suppress breastfeeding already established, 2 daily doses are required for 2 days. In hyperprolactinemia a weekly dose is administered and in Parkinson's disease a daily dose. Oral administration.
At the time of the last update, we found no published data on its excretion in breast milk.
No adverse effects have been reported in newborns whose mothers resume breastfeeding after a single dose to inhibit lactation (by mistake or subsequent reconsideration by the mother). If cabergoline was administered promptly to suppress lactation and it is desired to resume breastfeeding, the mother can do so immediately, attempting frequent breastfeeding to minimize the effect of the drug on milk production.
A mother who received ibuprofen and low doses of cabergoline on the 5th postpartum day for two days to treat severe breast engorgement with bleeding cracks was able to resume breastfeeding two days later with mechanical expression and direct breastfeeding. (Coban 2021)
No short- or long-term problems were observed in an infant breast-fed by a hyperprolactinemic mother taking cabergoline weekly. (Popescu 2022)
Expert authors advise treating nursing mothers with excess milk production (hyperlactation) with cabergoline at low doses (0.25 to 0.5 mg) every 3 to 5 days. (ABM protocol 32, 2020)
Cabergoline decreases prolactin production, inhibits postpartum lactation and has few and self-limited adverse effects (Humphrey 2022, Yang 2020, Bravo 2004, Bracco 1997, Giorda 1991, Caballero 1991, Melis1988 & 1987), such as headache, dizziness, nausea and vomiting. (Harris 2020, Bracco 1997, Giorda 1991)
With cabergoline there is less breastfeeding rebound effect than with bromocriptine and with fewer side effects. (European MSG 1991, Giorda 1991)
Cabergoline is the drug of choice for the treatment of hyperprolactinemia. (Bruehlman 2022)
There is no evidence that pharmacological treatments are more effective than no treatment in suppressing lactation in the first week postpartum. Expert authors and professional consensus contraindicate pharmacological treatment to suppress lactation.(Marcellin 2015, Sénat 2015, Prescrire 2013, Oladapo 2012)