Last update Jan. 27, 2021



Safe substance and/or breastfeeding is the best option.

Hyaluronidase is an enzyme that degrades, reversibly, connective tissue hyaluronic acid, improving the absorption and dispersion of fluids and drugs (local anesthetics, radiopaque agents...) injected intramuscularly or subcutaneously.
It is a natural product present in many tissues and fluids of the body.

Since the last update we have not found any published data on its excretion in breast milk.

Its high molecular weight makes it unlikely that it will pass into milk in significant amounts.

Due to its protein nature, it is inactivated in the gastrointestinal tract, and is not absorbed, (it has virtually no oral bioavailability), which hinders or prevents its transfer from breastmilk to infant .


We do not have alternatives for Hyaluronidase since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Hyaluronidase in other languages or writings:


Hyaluronidase belongs to this group or family:


Main tradenames from several countries containing Hyaluronidase in its composition:


Variable Value Unit
Oral Bioavail. ≈ 0 %
Molecular weight ≈ 54.000 daltons
0.03 hours


  1. Jung H. Hyaluronidase: An overview of its properties, applications, and side effects. Arch Plast Surg. 2020 Jul;47(4):297-300. Abstract
  2. FDA. Hyaluronidase. Drug Summary. 2012 Full text (in our servers)

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e-lactancia is a resource recommended by El Parto Es Nuestro of Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM