Last update Jan. 3, 2022

Human Immune globulin

Compatible

Safe product and/or breastfeeding is the best option.

Immunoglobulins (Ig) are proteins produced by B lymphocytes as a humoral response to antigens foreign to the body itself. The immunoglobulins used in clinical practice are preparations from human serum or plasma that contain antibodies, mainly IgG.

Its very high molecular weight make it highly unlikely that significant quantities will pass into breast milk. Administration of standard immunoglobulin does not significantly alter the levels of immunoglobulins (IgG or IgM) in colostrum or breast milk. (Palmeira 2009)

No problems have been observed in infants whose mothers are treated with immunoglobulin for various diseases (Gan 2012, Haas 2007 and 2000, Achiron 2004), except for one case of a rash that resolved spontaneously. (Bostan 2020)

Several medical societies and expert authors consider the use of this medication safe during breastfeeding. (Hale, LactMed, Flint 2016, Götestam 2016, Briggs 2016, Schaefer 2015, Butler 2014, Houtchens 2013, Østensen 2006)

List of WHO essential medicines: compatible with breastfeeding. (WHO / UNICEF 2002)

Alternatives

We do not have alternatives for Human Immune globulin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Human Immune globulin is also known as


Human Immune globulin in other languages or writings:

Group

Human Immune globulin belongs to this group or family:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 150.000 daltons
T½ 500 hours

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Bostan E, Gülseren D, Ersoy Evans S, Elçin G, Karaduman A, Atakan N. Efficacious treatment of pemphigus vulgaris by intravenous immunoglobulin during pregnancy and postpartum period. Dermatol Ther. 2020 Jan;33(1):e13187. Abstract
  4. Götestam Skorpen C, Hoeltzenbein M, Tincani A, Fischer-Betz R, Elefant E, Chambers C, da Silva J, Nelson-Piercy C, Cetin I, Costedoat-Chalumeau N, Dolhain R, Förger F, Khamashta M, Ruiz-Irastorza G, Zink A, Vencovsky J, Cutolo M, Caeyers N, Zumbühl C, Østensen M. The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis. 2016 May;75(5):795-810. Abstract Full text (link to original source) Full text (in our servers)
  5. Flint J, Panchal S, Hurrell A, van de Venne M, Gayed M, Schreiber K, Arthanari S, Cunningham J, Flanders L, Moore L, Crossley A, Purushotham N, Desai A, Piper M, Nisar M, Khamashta M, Williams D, Gordon C, Giles I; BSR and BHPR Standards, Guidelines and Audit Working Group. BSR and BHPR guideline on prescribing drugs in pregnancy and breastfeeding-Part I: standard and biologic disease modifying anti-rheumatic drugs and corticosteroids. Rheumatology (Oxford). 2016 Sep;55(9):1693-7. Abstract Full text (link to original source) Full text (in our servers)
  6. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, Third Edition. 2015
  7. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  8. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  9. Houtchens MK, Kolb CM. Multiple sclerosis and pregnancy: therapeutic considerations. J Neurol. 2013 Abstract
  10. Gan DC, Welsh B, Webster M. Successful treatment of a severe persistent case of pemphigoid gestationis with antepartum and postpartum intravenous immunoglobulin followed by azathioprine. Australas J Dermatol. 2012 Feb;53(1):66-9. Abstract
  11. Palmeira P, Costa-Carvalho BT, Arslanian C, Pontes GN, Nagao AT, Carneiro-Sampaio MM. Transfer of antibodies across the placenta and in breast milk from mothers on intravenous immunoglobulin. Pediatr Allergy Immunol. 2009 Sep;20(6):528-35. Abstract
  12. Haas J, Hommes OR. A dose comparison study of IVIG in postpartum relapsing-remitting multiple sclerosis. Mult Scler. 2007 Aug;13(7):900-8. Epub 2007 Mar 15. Abstract
  13. Østensen M, Khamashta M, Lockshin M, Parke A, Brucato A, Carp H, Doria A, Rai R, Meroni P, Cetin I, Derksen R, Branch W, Motta M, Gordon C, Ruiz-Irastorza G, Spinillo A, Friedman D, Cimaz R, Czeizel A, Piette JC, Cervera R, Levy RA, et al. Anti-inflammatory and immunosuppressive drugs and reproduction. Arthritis Res Ther. 2006 Abstract Full text (link to original source) Full text (in our servers)
  14. Achiron A, Kishner I, Dolev M, Stern Y, Dulitzky M, Schiff E, Achiron R. Effect of intravenous immunoglobulin treatment on pregnancy and postpartum-related relapses in multiple sclerosis. J Neurol. 2004 Sep;251(9):1133-7. Abstract
  15. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  16. Haas J. High dose IVIG in the post partum period for prevention of exacerbations in MS. Mult Scler. 2000 Oct;6 Suppl 2:S18-20; discussion S33. Abstract

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