Last update March 20, 2022

Histamine Hydrochloride

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Histamine exists naturally in our body. It is produced and stored in gastric cells, neurons, in the granules of mast cells and basophils, and in other cells. It is a neuronal neurotransmitter (Kovacova 2015) and an immunostimulant that protects lymphocytes. (EMA 2013)
It is used as a single dose in certain diagnostic tests and associated with interleukin II in the maintenance treatment of acute myeloid leukemia in two daily doses subcutaneously in ten cycles of 21 days with breaks of 3 to 6 weeks.

As of the last update, we found no published data on the excretion of histamine in breast milk.

Its pharmacokinetic data (wide volume of distribution, short half-life and alkaline pKa) make it very unlikely that significant quantities will pass into breast milk.
Histamine is rapidly cleared from plasma, with a half-life elimination of between 3 and 11 minutes according to Hale 2017 p450 and Middleton 2002, and 0.75 to 1.5 hours according to EMA 2013, clearance being twice as rapid in women. (EMA 2013)

Breast milk also has the power to degrade histamine because it contains the enzyme histaminase as an anti-inflammatory factor (Lawrence 2016 p183). In other words, the little that may have passed into the milk is destroyed in the milk itself and will not reach the infant.

This same enzyme, histaminase or diamine oxidase (DAO), present in the small intestine and ascending colon (and kidney), destroys ingested histamine and normally prevents significant amounts from entering plasma. (Kovacova 2015, Kanny 1999)
Thus, its low oral bioavailability makes it difficult for the infant to enter plasma from ingested breast milk, except in premature infants and the immediate neonatal period in which there may be greater intestinal permeability.

Some expert authors consider it prudent to wait two hours after exposure to breastfeed. (Hale 2017 p450)

See below the information of this related group:


We do not have alternatives for Histamine Hydrochloride since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Histamine Hydrochloride is also known as

Histamine Hydrochloride in other languages or writings:


Histamine Hydrochloride belongs to these groups or families:


Main tradenames from several countries containing Histamine Hydrochloride in its composition:


Variable Value Unit
Oral Bioavail. bajo - poor %
Molecular weight 184 daltons
VD 0.77 - 1.1 l/Kg
pKa 9.58 -
0.05 - 1.5 hours


  1. Hale TW, Rowe HE. Medications & Mothers' Milk. A Manual of Lactation Pharmacology. Springer Publishing Company. 2017
  2. Lawrence RA, Lawrence RM. Breastfeeding. A guide for the medical profession. Eighth Edition. Philadelphia: Elsevier; 2016
  3. Kovacova-Hanuskova E, Buday T, Gavliakova S, Plevkova J. Histamine, histamine intoxication and intolerance. Allergol Immunopathol (Madr). 2015 Sep-Oct;43(5):498-506. Abstract
  4. EMA. Histamina (Ceplene). Drug Summary. 2013 Full text (in our servers)
  5. EMA. Histamina (Ceplene). Ficha técnica. 2013 Full text (in our servers)
  6. Middleton M, Sarno M, Agarwala SS, Glaspy J, Laurent A, McMasters K, Naredi P, O'Day S, Whitman E, Danson S, Cosford R, Gehlsen K. Pharmacokinetics of histamine dihydrochloride in healthy volunteers and cancer patients: implications for combined immunotherapy with interleukin-2. J Clin Pharmacol. 2002 Jul;42(7):774-81. Abstract
  7. Kanny G, Bauza T, Frémont S, Guillemin F, Blaise A, Daumas F, Cabanis JC, Nicolas JP, Moneret-Vautrin DA. Histamine content does not influence the tolerance of wine in normal subjects. Allerg Immunol (Paris). 1999 Feb;31(2):45-8. Abstract

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