Last update May 21, 2021

Heptaminol Hydrochloride

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Vasodilator and cardiac stimulant that is marketed in association with other medications with purported and unproven properties such as to improve brain function, dizziness, and certain mental disorders.
There is no published clear evidence of its efficacy.
Oral use.

At the date of the last update, the authors did not find any published data on its excretion in breast milk.

The limited pharmacokinetic data available (low molecular weight, high pKa) make it likely that it may be transferred to breast milk in a possibly significant amount.

Product with very few bibliographic references, marketed in few countries.
Considered as a drug of low therapeutic utility (SEFAP 2012, INSALUD 2001) and even of risk to health (ANSM 2015).

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

In general, multiple drug combinations are not recommended, nor are drugs of unproven efficacy.


We do not have alternatives for Heptaminol Hydrochloride.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Heptaminol Hydrochloride in other languages or writings:


Heptaminol Hydrochloride belongs to this group or family:


Main tradenames from several countries containing Heptaminol Hydrochloride in its composition:


Variable Value Unit
Molecular weight 182 daltons
pKa 18.53 -


  1. AEMPS. Denubil (Deanol-Heptaminol). Ficha técnica. 2019 Full text (in our servers)
  2. ANSM. Agence nationale de sécurité du médicament et des produits de santé. Drugs for hypotension: disproportionate harms with etilefrine and heptaminol. . Prescrire Int. 2015 Jul;24(162):184. Abstract
  3. SEFAP. Sociedad Española de Farmacéuticos de Atención Primaria. Propuesta de medicamentos a desfinanciar por el Sistema Nacional de Salud. . 2012 Full text (in our servers)
  4. INSALUD. Área de Gestión de Farmacia. Subdirección General de Atención Primaria. Instituto Nacional de la Salud. Utilidad terapéutica de los medicamentos financiados por el Sistema Nacional de Salud. . 2001 Full text (in our servers)

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