Last update Sept. 4, 2022
Likely Compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Granisetron Hydrochloride is also known as Granisetron.
Granisetron Hydrochloride in other languages or writings:
Granisetron Hydrochloride belongs to these groups or families:
Main tradenames from several countries containing Granisetron Hydrochloride in its composition:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 60 | % |
Molecular weight | 312 | daltons |
Protein Binding | 65 | % |
VD | 3 | l/Kg |
pKa | 14.75 | - |
Tmax | 1 | hours |
T½ | 4 - 12 | hours |
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
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Antiemetic and antinauseous used in the prevention and treatment of nausea and vomiting induced by cytotoxic chemotherapy, radiotherapy and in the postoperative period. Intravenous administration in one or two daily doses.
At the date of the last update we did not find any published data on its excretion in breast milk.
Its pharmacokinetic data do not allow a good prediction of its possible excretion in breast milk, since while its low protein binding, low molecular weight and high pKA would facilitate it (Pistilli 2013), its very large volume of distribution would make it difficult.
Although some author considers it probably compatible (Mahadevan 2006), until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Pistilli 2013), especially during the neonatal period and in the event of prematurity.