Last update April 18, 2022

Гидрокортизон (topical use)

Compatible

Safe substance and/or breastfeeding is the best option.

Hydrocortisone or cortisol is a natural steroid produced in the adrenal cortex. It has glucocorticoid and, to a lesser extent, mineralocorticoid effects. Its esters are used as topical anti-inflammatories (dermatological, intestinal, ophthalmic and otic).

At the date of the last update we did not find any published data on its excretion in breast milk.

Topical use: The poor absorption through the skin and conjunctiva makes it unlikely that a significant amount will pass into breast milk. Bioavailability through the skin is less than 20% and after retention enema from 50 to 80%. (DrugBank acces.2022) 

Furthermore, its pharmacokinetic data (high percentage of protein binding, wide volume of distribution and short half-life) make it highly unlikely that significant quantities will pass into breast milk.

Whenever a treatment for nipple eczema or dermatitis is required, it should be applied right after the feed to make sure it has disappeared before the next nursing occurs. Otherwise, wipe cream out with a clean gauze. Do not continuously use for longer than a week.

Reportedly, a case of mineral-steroid toxicity has occurred due to continuous use of cream on the nipple. (De Stefano 1983)

Creams, gels or similar products that contain paraffin or mineral oil should not be used on the nipple to avoid absorption by the infant. (Concin 2008, Noti 2003)

Eleventh WHO Model List of Essential Drugs 2002: topical use compatible with breastfeeding. (WHO 2002)


See below the information of this related product:

Alternatives

We do not have alternatives for Гидрокортизон (topical use) since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Гидрокортизон (topical use) is Hydrocortisone, Topical Use (dermatological, ophthalmic, otic, intestinal enema) in Cyrillic.

Is written in other languages:

Гидрокортизон (topical use) is also known as

Tradenames

Main tradenames from several countries containing Гидрокортизон (topical use) in its composition:

  • Aftajuventus™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Antihemorroidal pomada rectal™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Anusol Duo™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Aquacort
  • Argisone™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Ciproxina™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Cohortan™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Cortane-B™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Cortisporin Ointment™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Cristalomicina™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Cyotic™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Dermanol™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Dermo Hubber™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Dermucor-H™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Hemorrane™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Isdinium
  • Kinogen (Italy)™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Lactisona
  • Mupax H™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Oralsone adultos
  • Oticin HC™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Oto-End™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Otomar-HC™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Paldar H™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Proctofoam-HC™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Proctol™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Proctomyxin HC™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Proctosedyl™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Proktosedon™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Ratio-Proctosone™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Shericur
  • Suniderma
  • Uniroid-HC™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Westcort
  • Xyloproct™. Contains other elements than Гидрокортизон (topical use) in its composition
  • Zoto-HC™. Contains other elements than Гидрокортизон (topical use) in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Dermat: 4 - 19 enema: 50 - 80 %
Molecular weight 363 daltons
Protein Binding 90 %
VD 0.48 - 1 l/Kg
pKa 12.59 -
Tmax 1 hours
1 - 2 hours

References

  1. DRUGBANK ONLINE. DrugBank.com 2006 - Consulted on Jan. 9, 2024 Full text (link to original source)
  2. CINFA. Antihemorroidal. Ficha técnica. 2022 Full text (in our servers)
  3. AEMPS. Hidrocortisona tópica. Ficha técnica. 2010 Full text (link to original source) Full text (in our servers)
  4. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  5. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  6. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  7. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000 Nov;16(4):319-31. Review. Erratum in: J Hum Lact 2001 Feb;17(1):90. Abstract
  8. De Stefano P, Bongo IG, Borgna-Pignatti C, Severi F. Factitious hypertension with mineralocorticoid excess in an infant. Helv Paediatr Acta. 1983 Abstract

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