Last update June 21, 2022

Габапентин

Compatible

Safe substance and/or breastfeeding is the best option.

Antiepileptic also used in the treatment of neuropathic pain and restless legs syndrome. Oral administration three times a day.

It is excreted in breast milk in a clinically insignificant amount (Kristensen 2006, Ohman 2005) and no problems have been observed in infants whose mothers took it. (Kristensen 2006, Ohman 2005, Johannessen 2005)

Plasma levels in these infants were either undetectable or very low. (Kristensen 2006, Ohman 2005)

A mother told us in 2016 that she was taking gabapentin while breastfeeding and when she increased the dose to 600 mg per day, she noticed that her six-month-old daughter was very sleepy all day.

Although discouraged in breastfeeding in some older articles (Mercadé 2012, Harden 2009), various medical societies, experts and expert consensus consider the use of this medication safe during breastfeeding. (Hale, Crettenand 2018, Reece 2017, Briggs 2015, Picéchietti 2015, Reimers 2014, Davanzo 2013, Pack 2006, Kristensen 2006, Bar-Oz 2000)


See below the information of this related product:

  • Maternal Epilepsy (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Габапентин is Gabapentin in Cyrillic.

Is written in other languages:

Габапентин is also known as

Groups

Габапентин belongs to these groups or families:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 60 %
Molecular weight 171 daltons
Protein Binding < 3 %
VD 0.8 l/Kg
pKa 4.6 -
Tmax 2 - 3 hours
T½ 5 - 7 hours
M/P ratio 0.8 - 1.3 -
Theoretical Dose 0.2 - 1.3 mg/Kg/d
Relative Dose 1.3 - 3.8 %
Ped.Relat.Dose 0.8 - 5.2 %

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  2. Crettenand M, Rossetti AO, Buclin T, Winterfeld U. [Use of antiepileptic drugs during breastfeeding : What do we tell the mother?] Nervenarzt. 2018 Abstract
  3. Reece-Stremtan Sarah, Campos Matilde, Kokajko Lauren, and The Academy of Breastfeeding Medicine. Breastfeeding Medicine. ABM Clinical Protocol #15: Analgesia and Anesthesia for the Breastfeeding Mother, Revised 2017. Breastfeed Med. 2017 Nov;12(9):500-506. Full text (link to original source) Full text (in our servers)
  4. Jacob S, Nair AB. An Updated Overview on Therapeutic Drug Monitoring of Recent Antiepileptic Drugs. Drugs R D. 2016 Abstract Full text (link to original source) Full text (in our servers)
  5. Picchietti DL, Hensley JG, Bainbridge JL, Lee KA, Manconi M, McGregor JA, Silver RM, Trenkwalder C, Walters AS; International Restless Legs Syndrome Study Group (IRLSSG).. Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation. Sleep Med Rev. 2015 Abstract
  6. Veiby G, Bjørk M, Engelsen BA, Gilhus NE. Epilepsy and recommendations for breastfeeding. Seizure. 2015 May;28:57-65. Abstract Full text (link to original source)
  7. Grover S, Avasthi A. Mood stabilizers in pregnancy and lactation. Indian J Psychiatry. 2015 Abstract Full text (link to original source) Full text (in our servers)
  8. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  9. Reimers A. New antiepileptic drugs and women. Seizure. 2014 Abstract Full text (link to original source) Full text (in our servers)
  10. Pfizer. Gabapentin. Drug Summary. 2014 Full text (in our servers)
  11. Davanzo R, Dal Bo S, Bua J, Copertino M, Zanelli E, Matarazzo L. Antiepileptic drugs and breastfeeding. Ital J Pediatr. 2013 Abstract Full text (link to original source) Full text (in our servers)
  12. Mercadé Cerdá JM, Sancho Rieger J, Mauri Llerda JA, López González FJ,Salas Puig X. Guías diagnósticas y terapéuticas de la Sociedad Española de Neurología 2012. 1. Guía oficial de práctica clínica en epilepsia. Guías SEN 2012 Full text (in our servers)
  13. Harden CL, Pennell PB, Koppel BS, Hovinga CA, Gidal B, Meador KJ, Hopp J, Ting TY, Hauser WA, Thurman D, Kaplan PW, Robinson JN, French JA, Wiebe S, Wilner AN, Vazquez B, Holmes L, Krumholz A, Finnell R, Shafer PO, Le Guen C; American Academy of Neurology; et al. Practice parameter update: management issues for women with epilepsy--focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of... Neurology. 2009 Abstract Full text (link to original source) Full text (in our servers)
  14. AEMPS. Gabapentina. Ficha técnica. 2007 Full text (in our servers)
  15. Kristensen JH, Ilett KF, Hackett LP, Kohan R. Gabapentin and breastfeeding: a case report. J Hum Lact. 2006 Abstract
  16. Pack AM. Therapy insight: clinical management of pregnant women with epilepsy. Nat Clin Pract Neurol. 2006 Abstract
  17. Ohman I, Vitols S, Tomson T. Pharmacokinetics of gabapentin during delivery, in the neonatal period, and lactation: does a fetal accumulation occur during pregnancy? Epilepsia. 2005 Abstract Full text (link to original source) Full text (in our servers)
  18. Johannessen SI, Helde G, Brodtkorb E. Levetiracetam concentrations in serum and in breast milk at birth and during lactation. Epilepsia. 2005 May;46(5):775-7. Abstract Full text (link to original source) Full text (in our servers)

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