Last update Nov. 15, 2023

Fluorescein Sodium

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Fluorescein, in its sodium form, is a dye used intravenously or orally in angiography or angioscopy of the iris and retina. It is also used topically (eye drops) to detect corneal lesions and foreign bodies in the eye. It has been used the fluorescein dilaurate orally for the diagnosis of exocrine pancreatic function.

After intravenous administration, fluorescein is excreted in breast milk in very small but potentially significant amounts (Maquire 1988). After topical administration as eye drops, levels in breast milk are negligible. (Mattern 1990)

As it is a photosensitizing substance, it may be advisable to avoid exposing the infant to intense light (including phototherapy) for a few days after intravenous administration (Lopez 2015, Maquire 1988). It may be advisable to avoid intravenous use in mothers of premature infants or infants under 1 month of age. (WHO 2002)

After topical ocular administration, no precautions are necessary; absorption can be minimized by pressing with the finger on the tear duct (inner canthus of the eye) for 1-2 minutes and administering the dose immediately after breastfeeding. (Belkin 2020, Blumen 2020)

American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding. (AAP 2001)

Alternatives

We do not have alternatives for Fluorescein Sodium.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Fluorescein Sodium in other languages or writings:

Group

Fluorescein Sodium belongs to this group or family:

Tradenames

Main tradenames from several countries containing Fluorescein Sodium in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 50 %
Molecular weight 376 daltons
Protein Binding 70 - 85 %
VD 0.5 l/Kg
Tmax 1 hours
4.4 (plasma). 62 (leche) hours
M/P ratio 0.5 -
Theoretical Dose 0.059 mg/Kg/d
Relative Dose 0.67 %

References

  1. Blumen-Ohana E, Sellem E. [Pregnancy & glaucoma: SFO-SFG recommendations]. J Fr Ophtalmol. 2020 Jan;43(1):63-66. Abstract
  2. Belkin A, Chen T, DeOliveria AR, Johnson SM, Ramulu PY, Buys YM; American Glaucoma Society and the Canadian Glaucoma Society.. A Practical Guide to the Pregnant and Breastfeeding Patient with Glaucoma. Ophthalmol Glaucoma. 2020 Mar - Apr;3(2):79-89. Abstract
  3. Lopez-Yang CE, Garcia CA. Persistent unilateral central serous chorioretinopathy in a breastfeeding woman. BMJ Case Rep. 2015 Jan 7;2015. pii: bcr2014206719. Abstract Full text (link to original source)
  4. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  5. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  6. Mattern J, Mayer PR. Excretion of fluorescein into breast milk. Am J Ophthalmol. 1990 May 15;109(5):598-9. No abstract available. Abstract
  7. Maquire AM, Bennett J. Fluorescein elimination in human breast milk. Arch Ophthalmol. 1988 Jun;106(6):718-9. No abstract available. Abstract

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