Last update Jan. 28, 2025

Fluocinolone Acetonide

Compatible

Safe product and/or breastfeeding is the best option.

Fluocinolone acetonide is a corticosteroid with very high glucocorticoid activity, used topically in various inflammatory diseases of the skin, eyes, ears and nose and intravitreally in the treatment of chronic posterior uveitis and diabetic macular oedema.

At the time of the last update, we found no published data on its excretion in breast milk.

Low absorption through the skin makes passage of significant amounts into breast milk unlikely.

If required to treat eczema or nipple dermatosis it is advisable to choose the least potent corticosteroid, apply it just after feeding so that it has been reabsorbed before the next feeding, if necessary remove any residues with gauze and do not use for more than a week at a time.

Mineralcorticoid intoxication has occurred in an infant due to continuous application of a corticoid to the nipple. (De Stefano 1983)

Avoid application of creams, gels and other locally applied products containing paraffin (mineral oil) on the nipple so that they are not absorbed by the infant. (Concin 2008, Noti 2003)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Fluocinolone Acetonide in other languages or writings:

Tradenames

Main tradenames from several countries containing Fluocinolone Acetonide in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 453 daltons

References

  1. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  2. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  3. De Stefano P, Bongo IG, Borgna-Pignatti C, Severi F. Factitious hypertension with mineralocorticoid excess in an infant. Helv Paediatr Acta. 1983 Abstract

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