Last update Jan. 7, 2022

Flubendazole

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

It is an analogue of mebendazole with similar actions and uses. Indicated in the treatment of ascariasis, hookworms infections and trichuriasis. Oral administration.

Since the last update we have not found any published data on its excretion in breast milk.

Its very high percentage of protein binding make it highly unlikely that significant quantities will pass into breast milk.

Its low oral bioavailability hinders transfer to infant plasma from breastmilk, except in premature infants and the immediate neonatal period when there may be increased intestinal permeability.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Schaefer 2015, especially during the neonatal period and in the event of prematurity.

Alternatives

  • Albendazole (Safe product and/or breastfeeding is the best option.)
  • Mebendazole (Safe product and/or breastfeeding is the best option.)
  • Niclosamide (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Flubendazole is also known as


Flubendazole in other languages or writings:

Group

Flubendazole belongs to this group or family:

Tradenames

Main tradenames from several countries containing Flubendazole in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Baja - Low %
Molecular weight 313 daltons
Protein Binding 90 %
pKa 9.17 -

References

  1. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, Third Edition. 2015

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