Last update Jan. 24, 2017

Flavoxate Hydrochloride

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Anticholinergic and smooth-muscle relaxant with antimuscarinic action which is used to relieve spasticity, inflammation, pain and incontinence of the urine bladder tract.

At latest update relevant published data on its excretion into breast milk were not found.

The antimuscarinic effect may reduce milk production (De Martino 1980, Bizarro 1980), albeit only during the first weeks postpartum.

Side effects occur very rarely with a rather low risk during lactation when timely used. Monitoring of milk production and anticholinergic symptoms in the infant such as irritability, nausea or constipation would be desirable.

Until more published data on this drug related to breastfeeding is available, an alternative with a known pharmacokinetic profile that should appear safer while breastfeeding (higher protein-binding capacity, lower half-life span and lower oral bioavailability) may be preferable, especially during the neonatal period and in case of prematurity.


  • Oxybutynin (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Tolterodine Tartrate (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Flavoxate Hydrochloride in other languages or writings:


Flavoxate Hydrochloride belongs to this group or family:


Main tradenames from several countries containing Flavoxate Hydrochloride in its composition:


Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 428 daltons
VD 2.9 l/Kg
Tmax 1 - 2 hours
3.5 - 10 hours


  1. Guay DR. Clinical pharmacokinetics of drugs used to treat urge incontinence. Clin Pharmacokinet. 2003 Abstract
  2. Bizzarro A, Iannucci F, Tolino A, Soricelli A, Guarino G, Verdoliva A. Inhibiting effect of atropine on prolactin blood levels after stimulation with TRH. Clin Exp Obstet Gynecol. 1980 Abstract
  3. De Martino F, De Matteo A, L'Abbate V, Soricelli A, Fontana A, Petrenga E, Cesarone M. [Inhibitory effects of atropine on serum prolactin levels after TRH stimulation]. Boll Soc Ital Biol Sper. 1980 Abstract
  4. Bertoli M, Conti F, Conti M, Cova A, Setnikar I. Pharmacokinetics of Flavoxate in man. Pharmacol Res Commun. 1976 Abstract

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