Last update Oct. 17, 2024

Фенформина Гидрохлорид

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Biguanide oral antidiabetic. Biguanides decrease hepatic neoglycogenesis and have little risk of hypoglycemia.

At the date of the last update we did not find any published data on its excretion in breast milk.

High risk of severe lactic acidosis. It has been withdrawn from the market in most countries of the world. (Yendapally 2020)

Oral anti-diabetic drugs are useless for treatment of diabetes type 1. For diabetes type 2, diet and exercise are advisable. Breastfeeding helps to lower glucemia level. 


See below the information of this related product:

  • Maternal Diabetes mellitus (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Фенформина Гидрохлорид is Phenformin Hydrochloride in Cyrillic.

Is written in other languages:

Tradenames

Main tradenames from several countries containing Фенформина Гидрохлорид in its composition:

  • Azucaps
  • Bidiabe™. Contains other elements than Фенформина Гидрохлорид in its composition
  • Debei
  • Debeina
  • Diabis
  • Gliben F™. Contains other elements than Фенформина Гидрохлорид in its composition
  • Glinorboral Comp™. Contains other elements than Фенформина Гидрохлорид in its composition

Pharmacokinetics

Variable Value Unit
Molecular weight 242 daltons
Protein Binding 8 %
pKa 19.18 -
11 hours

References

  1. Yendapally R, Sikazwe D, Kim SS, Ramsinghani S, Fraser-Spears R, Witte AP, La-Viola B. A review of phenformin, metformin, and imeglimin. Drug Dev Res. 2020 Jun;81(4):390-401. Abstract

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America

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