Last update July 25, 2025

Evening Primrose

Compatible

Safe product and/or breastfeeding is the best option.

The oil from the seeds, the plant in infusion and the root are used as a food supplement. It contains 14% essential oil rich in cis-linolenic acid (70%) and gamma-linoleic acid (GLA) (10%), both precursors of prostaglandins, as well as palmitic acid (10%) and stearic acid (10%). Attributed properties: anti-inflammatory, antioxidant, antiplatelet. There is controversial evidence (WHO 2002) of its efficacy in atopic dermatitis, premenstrual syndrome (Hardy 2000), mastalgia (Wetzig 1994), multiple sclerosis, psychiatric disorders and rheumatic diseases, including Raynaud's syndrome (Anderson 2004, Chrubasik 2002). Its efficacy as a labour inducer is disputed, and serious adverse effects have been reported with the use of evening primrose oil during pregnancy. (Dante 2014)

The administration of evening primrose oil for several months to breastfeeding mothers increases the levels of fatty acids in milk without causing adverse effects in either the mother or the infant. (Cant 1991)

Cis and gamma-linoleic acids are natural constituents of breast milk (Amir 2011). The total concentration of fat and linolenic acid in banked milk is reduced due to pasteurisation and freezing (Vázquez 2014, García-Lara 2013 and 2012, Wardell 1981). The addition of evening primrose oil ingredients to commercial infant formulas for premature babies is suggested. (Woltil 1999)

The administration of AGL to mothers does not prevent the onset of atopic dermatitis in infants. (Kitz 2006)

There is no evidence that evening primrose oil is effective in treating Raynaud's phenomenon of the nipple. (Anderson 2004)

It is a plant widely used by breastfeeding mothers (Amer 2015). Given its lack of toxicity, moderate consumption is considered acceptable during breastfeeding. (The Royal 2013)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Evening Primrose is also known as


Evening Primrose in other languages or writings:

Tradenames

Main tradenames from several countries containing Evening Primrose in its composition:

References

  1. Amer MR, Cipriano GC, Venci JV, Gandhi MA. Safety of Popular Herbal Supplements in Lactating Women. J Hum Lact. 2015 Abstract
  2. Vázquez-Román S, Alonso-Díaz C, García-Lara NR, Escuder-Vieco D, Pallás-Alonso CR. Medida por crematocrito del contenido calórico de la leche materna donada congelada. [Effect of freezing on the "creamatocrit" measurement of the lipid content of human donor milk]. An Pediatr (Barc). 2014 Abstract Full text (in our servers)
  3. Dante G, Bellei G, Neri I, Facchinetti F. Herbal therapies in pregnancy: what works? Curr Opin Obstet Gynecol. 2014 Abstract Full text (link to original source)
  4. García-Lara NR, Vieco DE, De la Cruz-Bértolo J, Lora-Pablos D, Velasco NU, Pallás-Alonso CR. Effect of Holder pasteurization and frozen storage on macronutrients and energy content of breast milk. J Pediatr Gastroenterol Nutr. 2013 Abstract
  5. The Royal Women’s Hospital Victoria Australia. Herbal and Traditional Medicines in Breasfeeding. Fact Sheet. 2013 Full text (link to original source) Full text (in our servers)
  6. García-Lara NR, Escuder-Vieco D, García-Algar O, De la Cruz J, Lora D, Pallás-Alonso C. Effect of freezing time on macronutrients and energy content of breastmilk. Breastfeed Med. 2012 Abstract Full text (link to original source) Full text (in our servers)
  7. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011 Sep;40(9):684-90. Review. Abstract
  8. Kitz R, Rose MA, Schönborn H, Zielen S, Böhles HJ. Impact of early dietary gamma-linolenic acid supplementation on atopic eczema in infancy. Pediatr Allergy Immunol. 2006 Abstract
  9. Anderson JE, Held N, Wright K. Raynaud's phenomenon of the nipple: a treatable cause of painful breastfeeding. Pediatrics. 2004 Abstract Full text (link to original source) Full text (in our servers)
  10. WHO. World Health Organization. Geneva. WHO monographs on selected medicinal plants. Volume 2. WHO monographs. 2002 Full text (link to original source) Full text (in our servers)
  11. Chrubasik S, Pollak S. [Pain management with herbal antirheumatic drugs]. Wien Med Wochenschr. 2002 Abstract
  12. Hardy ML. Herbs of special interest to women. J Am Pharm Assoc (Wash). 2000 Abstract
  13. Woltil HA, van Beusekom CM, Schaafsma A, Okken A, Muskiet FA. Does supplementation of formula with evening primrose and fish oils augment long chain polyunsaturated fatty acid status of low birthweight infants to that of breast-fed counterparts? Prostaglandins Leukot Essent Fatty Acids. 1999 Abstract
  14. Wetzig NR. Mastalgia: a 3 year Australian study. Aust N Z J Surg. 1994 Abstract
  15. Cant A, Shay J, Horrobin DF. The effect of maternal supplementation with linoleic and gamma-linolenic acids on the fat composition and content of human milk: a placebo-controlled trial. J Nutr Sci Vitaminol (Tokyo). 1991 Abstract
  16. Wardell JM, Hill CM, D'Souza SW. Effect of pasteurization and of freezing and thawing human milk on its triglyceride content. Acta Paediatr Scand. 1981 Abstract

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