Last update Sept. 4, 2021
Epoprostenol or prostacyclin is a prostaglandin with strong vasodilator and antithrombotic properties which works by inhibiting platelet aggregation. Prostacyclin is the natural prostaglandin that exists in the body and is also present in breast milk.
Indicated in the treatment of pulmonary arterial hypertension and in dialysis when heparin is contraindicated.
Administration by intravenous infusion.
At the date of the last update, there was no available published data on its excretion in breast milk.
Its acid pKa and large volume of distribution, as well as its very fast elimination half-life (T½ of 6 minutes) make it unlikely to pass into breast milk.
Its low oral bioavailability makes it difficult for the infant to pass into plasma from ingested breast milk.
It is a medication that is used in newborns, including premature (Berger 2019).
Prostaglandins in breast milk are synthesized in the mammary gland and are not dependent on plasma levels (Friedman 1986).
Plasma levels of prostacyclin decrease during breastfeeding and return to their normal level after breastfeeding (Ylikorkala 1981).
We do not have alternatives for Epoprostenol.
Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.
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