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A gonadotropin-releasing hormone (GnRH) receptor antagonist indicated for the treatment of moderate to severe pain associated with endometriosis. It produces a dose-dependent suppression of luteinising hormone (LH) and follicle-stimulating hormone (FSH), leading to a decrease in blood levels of the ovarian sex hormones, oestradiol and progesterone. It is administered orally, in one or two daily doses.
As of the last update, no information is available on the use of elagolix during breastfeeding.
Its pharmacokinetic data (very large volume of distribution, moderately high molecular weight and plasma protein binding, and short half-life) make it unlikely that clinically significant amounts will pass into breast milk.
Until further published data on this drug in relation to breastfeeding become available, known safer alternatives may be preferable, especially during the neonatal period and in cases of prematurity.
As milk production depends on minimum levels of oestrogen, this product could theoretically reduce milk production.