Last update Sept. 4, 2022

Dolasetron Mesylate

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Dolasetron is an antinauseant and antiemetic, 5-HT3 antagonist, used in chemotherapy and postoperatively. Oral or intravenous administration.

Since the last update we have not found published data on its excretion in breastmilk.

Its pharmacokinetic data (moderately high molecular weight and wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.

Although some author considers it probably compatible (Mahadevan 2006), until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Pistilli 2013), especially during the neonatal period and in the event of prematurity.

Alternatives

  • Domperidone (Safe substance and/or breastfeeding is the best option.)
  • Metoclopramide (Safe substance and/or breastfeeding is the best option.)
  • Ondansetron (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Dolasetron Mesylate in other languages or writings:

Groups

Dolasetron Mesylate belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Dolasetron Mesylate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 75 %
Molecular weight 421 daltons
Protein Binding 69 - 77 %
VD 5.8 l/Kg
pKa 12.18 -
Tmax 1 hours
T½ 8.1 hours

References

  1. Pistilli B, Bellettini G, Giovannetti E, Codacci-Pisanelli G, Azim HA Jr, Benedetti G, Sarno MA, Peccatori FA. Chemotherapy, targeted agents, antiemetics and growth-factors in human milk: how should we counsel cancer patients about breastfeeding? Cancer Treat Rev. 2013 May;39(3):207-11. Abstract
  2. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)

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