Last update Nov. 5, 2014

Dirithromycin

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Be aware of the possibility of false negative bacterial cultures when the mother is on antibiotics.

Alternatives

  • Azithromycin (Safe substance and/or breastfeeding is the best option.)
  • Clarithromycin (Safe substance and/or breastfeeding is the best option.)
  • Erythromycin (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Group

Dirithromycin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Dirithromycin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 14 %
Molecular weight 837 daltons
Protein Binding 15 %
Tmax 4 hours
T½ 44 hours

References

  1. Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001 Feb;17(1):54-65. Abstract

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America

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