Last update Dec. 26, 2021

Diacerein

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is an anthraquinone derivative that is used in osteoarthritis. It metabolizes to rhein (rhubarb anthraquinone glycoside) which acts as an interleukin-1 inhibitor. Oral administration twice daily.

Since the last update we have not found any published data on its excretion in breast milk.

Its pharmacokinetic characteristics (high plasma protein binding, large volume of distribution and low pKa) make it very unlikely its excretion into breast milk in significant amounts.

The most common and serious side effect possible is diarrhea, which can lead to dehydration and complicate breastfeeding.

Alternatives

  • Celecoxib ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Glucosamine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Paracetamol ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Diacerein is also known as


Diacerein in other languages or writings:

Tradenames

Main tradenames from several countries containing Diacerein in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 50 - 60 %
Molecular weight 368 daltons
Protein Binding 99 %
VD 0.2 - 0.9 l/Kg
pKa 3.37 -
Tmax 2 hours
T1/2 4 - 10 hours

References

  1. Pelletier JP, Raynauld JP, Dorais M, Bessette L, Dokoupilova E, Morin F, Pavelka K, Paiement P, Martel-Pelletier J; DISSCO Trial Investigator Group.. An international, multicentre, double-blind, randomized study (DISSCO): effect of diacerein vs celecoxib on symptoms in knee osteoarthritis. Rheumatology (Oxford). 2020 Dec 1;59(12):3858-3868. Abstract
  2. Normon. Diacereína. Ficha técnica. 2017 Full text (in our servers)

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