Last update July 27, 2022

Dexketoprofen Trometamol


Safe substance and/or breastfeeding is the best option.

S - (+) active enantiomer of ketoprofen with similar structure, pharmacokinetics and anti-inflammatory, anti-allergic and antipyretic properties (Valles 2006, Barbanoj 2001). Oral or intravenous administration in two - three daily doses. Also used as a gel or cream for topical use.

Since the last update we have not found published data on its excretion in breastmilk. But it is presumed to be similar to that of its enantiomer, ketoprofen, whose excretion in milk is insignificant (Jacqz-Aigrain 2007). Its high percentage of protein binding and short half-life make it unlikely it will transfer into breastmilk in significant amounts.

Most nonsteroidal anti-inflammatory drugs can increase jaundice, so it is preferable to avoid them during the neonatal period in mothers of infants with jaundice. (Janssen 2000).

Because there is less published information than with other drugs in the same group, safer known alternatives may be preferable, especially during the neonatal period and in cases of prematurity.

TOPICAL USE: The forms of cutaneous application have very low systemic absorption through the skin and are compatible with breastfeeding.

See below the information of this related product:

  • Ketoprofen (Safe substance and/or breastfeeding is the best option.)


  • Ibuprofen (Safe substance and/or breastfeeding is the best option.)
  • Ketoprofen (Safe substance and/or breastfeeding is the best option.)
  • Paracetamol (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Dexketoprofen Trometamol is also known as

Dexketoprofen Trometamol in other languages or writings:


Main tradenames from several countries containing Dexketoprofen Trometamol in its composition:


Variable Value Unit
Oral Bioavail. 85 %
Molecular weight 254 daltons
Protein Binding 99 %
VD 0.25 l/Kg
pKa 3.88 -
Tmax 0.25 - 1 hours
1.65 hours


  1. AEMPS. Dexketoprofeno (Enantyum inyectable). Ficha técnica. 2021 Full text (in our servers)
  2. Menarini. Dexketoprofen (Keral). Drug Summary 2018 Full text (in our servers)
  3. AEMPS. Dexketoprofeno. Ficha técnica. 2013 Full text (in our servers)
  4. Jacqz-Aigrain E, Serreau R, Boissinot C, Popon M, Sobel A, Michel J, Sibony O. Excretion of ketoprofen and nalbuphine in human milk during treatment of maternal pain after delivery. Ther Drug Monit. 2007 Abstract
  5. Valles J, Artigas R, Crea A, Muller F, Paredes I, Zapata A, Capriati A. Clinical pharmacokinetics of parenteral dexketoprofen trometamol in healthy subjects. Methods Find Exp Clin Pharmacol. 2006 Jun;28 Suppl A:7-12. Abstract
  6. Barbanoj MJ, Antonijoan RM, Gich I. Clinical pharmacokinetics of dexketoprofen. Clin Pharmacokinet. 2001;40(4):245-62. Review. Abstract
  7. Janssen NM, Genta MS. The effects of immunosuppressive and anti-inflammatory medications on fertility, pregnancy, and lactation. Arch Intern Med. 2000 Abstract Full text (link to original source) Full text (in our servers)

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