Last update July 24, 2014

Demeclocycline

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Although it is secreted into breast milk it has not been detected in infant’s blood because it forms unabsorbable chelate compounds with milk calcium. It is not recommended a long-term use (more than 3-4 weeks) since damage on bone growth plates, teeth discoloration, or alteration of intestinal flora may occur.

Be aware of the possibility of false negative results of bacterial cultures when the mother is on antibiotics.

Withdrawn from the market in Spain.

Alternatives

  • Tetracycline ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Demeclocycline is also known as


Group

Demeclocycline belongs to this group or family:

Tradenames

Main tradenames from several countries containing Demeclocycline in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 66 %
Molecular weight 501 daltons
Protein Binding 70 %
Tmax 4 hours
12 hours
M/P ratio 0.7 -
Theoretical Dose 0.15 mg/Kg/d
Relative Dose 1.5 %

References

  1. Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001 Feb;17(1):54-65. Abstract

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America

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