Last update May 22, 2023

Daptomycin

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

It is a cyclic lipopeptide antibacterial agent with a broad spectrum of activity against Gram-positive bacteria, including methicillin-sensitive and resistant Staphylococcus aureus and vancomycin-resistant enterococci. Intravenous administration once a day.

It is excreted in breast milk in clinically insignificant amounts (Dei Cas 2019, Cesari 2018, Buitrago 2009) and no problems have been observed in infants whose mothers were treated with Daptomycin. (Cesari 2018, Buitrago 2009) ​​

Expert authors consider the use of this medication to be safe or very probably safe during breastfeeding. (Hale, LactMed, Briggs 2015, Schaefer 2015)

Alternatives

We do not have alternatives for Daptomycin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Daptomycin in other languages or writings:

Group

Daptomycin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Daptomycin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. ≈ 0 %
Molecular weight 1.621 daltons
Protein Binding 92 (90 - 94) %
VD 0.1 - 0.2 l/Kg
pKa 2.98 -
Tmax 0.5 hours
7.5 - 9 hours
M/P ratio 0.001 -
Theoretical Dose 0.003 - 0.007 mg/Kg/d
Relative Dose 0.1 - 0.5 %

References

  1. Dei Cas M, Casagni E, Gambaro V, Cesari E, Roda G. Determination of daptomycin in human plasma and breast milk by UPLC/MS-MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 May 15;1116:38-43. Abstract Full text (link to original source)
  2. Cesari E, Roda G, Visconti GL, Ramondino S, Dei Cas M, Monina G, Gambaro V. Daptomycin excretion into human milk. Br J Clin Pharmacol. 2018 Feb;84(2):394-395. Abstract Full text (link to original source)
  3. Buitrago MI, Crompton JA, Bertolami S, North DS, Nathan RA. Extremely low excretion of daptomycin into breast milk of a nursing mother with methicillin-resistant Staphylococcus aureus pelvic inflammatory disease. Pharmacotherapy. 2009 Mar;29(3):347-51. Abstract

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